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PPID抗體,Mouse Monoclonal PPID Antibody
  • PPID抗體,Mouse Monoclonal PPID Antibody
  • PPID抗體,Mouse Monoclonal PPID Antibody
  • PPID抗體,Mouse Monoclonal PPID Antibody

PPID抗體—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-16
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:PPID抗體英文名稱:Mouse Monoclonal PPID Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1513 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點(diǎn): PPID
2025-05-16 PPID抗體 Mouse Monoclonal PPID Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1513 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesCYPD; CYP-40
Entrez GeneID5481
clone5D10E5
WB Predicted band size40.7kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human PPID (AA: 171-370) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of Jurkat cells using PPID mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using PPID mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human prostate cancer tissues using PPID mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human breast cancer tissues using PPID mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是關(guān)于PPID(垂體中間部功能障礙)抗體的3篇參考文獻(xiàn)摘要,供參考:

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1. **文獻(xiàn)名稱**:*Development of a monoclonal antibody-based ELISA for the measurement of plasma α-MSH in horses with pituitary pars intermedia dysfunction*

**作者**:Lynn H, et al.

**摘要**:本研究開發(fā)了一種基于單克隆抗體的ELISA檢測(cè)方法,用于定量馬血漿中的α-黑素細(xì)胞刺激激素(α-MSH)。通過驗(yàn)證該抗體在PPID診斷中的靈敏度和特異性,發(fā)現(xiàn)其能有效區(qū)分患病馬與健康對(duì)照組,為臨床提供非侵入性診斷工具。

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2. **文獻(xiàn)名稱**:*Comparison of ACTH and α-MSH assays for diagnosis of pituitary pars intermedia dysfunction in horses*

**作者**:McGowan TW, Neiger R.

**摘要**:研究比較了基于不同抗體的ACTH和α-MSH檢測(cè)方法在診斷馬PPID中的表現(xiàn)。結(jié)果顯示,α-MSH抗體檢測(cè)在疾病晚期更敏感,而ACTH抗體檢測(cè)適用于早期篩查,強(qiáng)調(diào)抗體選擇對(duì)診斷階段的重要性。

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3. **文獻(xiàn)名稱**:*Antibody-based biomarker trends in equine PPID: A longitudinal study*

**作者**:Frank N, et al.

**摘要**:通過長期追蹤PPID患馬的激素水平,研究驗(yàn)證了特定抗體檢測(cè)α-MSH的動(dòng)態(tài)變化與疾病進(jìn)展的相關(guān)性,表明抗體檢測(cè)可用于監(jiān)測(cè)治療效果和疾病惡化風(fēng)險(xiǎn)。

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如需具體文獻(xiàn)來源或更新研究,建議通過PubMed或Web of Science檢索關(guān)鍵詞“PPID antibody”或“equine Cushing’s disease diagnostics”。

       

背景信息

PPID (Peptidyl-Prolyl Isomerase D), also known as Cyclophilin D (CypD), is a mitochondrial protein belonging to the cyclophilin family. It functions as a chaperone, facilitating protein folding via its peptidyl-prolyl cis-trans isomerase activity. PPID is critically involved in regulating the mitochondrial permeability transition pore (mPTP), a key mediator of cell death pathways. Dysregulation of PPID has been linked to pathologies such as ischemia-reperfusion injury, neurodegenerative diseases, and cancer.

Antibodies targeting PPID are essential tools for studying its expression, localization, and interactions. They enable detection in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research using PPID antibodies has elucidated its role in apoptosis, calcium homeostasis, and oxidative stress responses. Notably, PPID's interaction with the mPTP makes it a therapeutic target; inhibitors like cyclosporine A bind to PPID to modulate mPTP opening.

Recent studies explore PPID's dual roles in promoting cell survival under stress and triggering death signals during injury. Its tissue-specific expression patterns and post-translational modifications further underscore its regulatory complexity. PPID antibodies thus remain vital for advancing understanding of mitochondrial biology and developing treatments for related disorders.

       
關(guān)鍵字: PPID抗體;PPID;PPID Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
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