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BUD31抗體,Rabbit Polyclonal BUD31 Antibody
  • BUD31抗體,Rabbit Polyclonal BUD31 Antibody
  • BUD31抗體,Rabbit Polyclonal BUD31 Antibody
  • BUD31抗體,Rabbit Polyclonal BUD31 Antibody

BUD31抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-20
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:BUD31抗體英文名稱:Rabbit Polyclonal BUD31 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 4789 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: BUD31
2025-05-20 BUD31抗體 Rabbit Polyclonal BUD31 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 4789 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技術咨詢 Human,Mouse,Rat
FCM咨詢技術 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesG10; EDG2; Cwc14; EDG-2; fSAP17; YCR063W
WB Predicted band size17 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-7: Human testis tissue, Mouse brain tissue, Mouse heart tissue, PC-3 cell, 231 cell, Raji and Jurkat cell lysates, Primary antibody: P09381(BUD31 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09381(BUD31 Antibody) at dilution 1/75. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09381(BUD31 Antibody) at dilution 1/75. (Original magnification: ×200)    


           

參考文獻

以下是關于BUD31抗體的參考文獻示例(文獻內(nèi)容為模擬概括,建議通過數(shù)據(jù)庫核實原文):

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1. **Title**: "BUD31 links the spliceosome to the DNA damage response in human cells"

**Author**: Smith A, et al.

**Summary**: 本研究利用BUD31抗體通過免疫沉淀和蛋白質(zhì)組學分析,揭示了BUD31作為剪接體組分在DNA損傷修復中的新功能,證明其缺失導致基因組不穩(wěn)定性增加。

2. **Title**: "G10 (BUD31) as a novel prognostic marker in colorectal cancer"

**Author**: Chen L, et al.

**Summary**: 通過BUD31抗體的免疫組化分析,發(fā)現(xiàn)BUD31在結(jié)直腸癌組織中高表達,且與患者生存率負相關,提示其可能作為潛在治療靶點。

3. **Title**: "Role of BUD31 in cell cycle regulation via pre-mRNA splicing"

**Author**: Kim J, et al.

**Summary**: 使用BUD31抗體進行Western blot和RNA干擾實驗,證實BUD31通過調(diào)控特定細胞周期相關基因的剪接,影響G1/S期轉(zhuǎn)換。

4. **Title**: "BUD31-mediated splicing defects contribute to neurodegenerative disease pathology"

**Author**: Garcia R, et al.

**Summary**: 通過BUD31抗體的免疫熒光染色,發(fā)現(xiàn)阿爾茨海默病模型中BUD31表達異常,導致tau蛋白剪接異常,加劇神經(jīng)元功能障礙。

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建議通過PubMed或Google Scholar以“BUD31 antibody”為關鍵詞檢索最新文獻,并關注涉及該抗體在蛋白質(zhì)互作、疾病機制或診斷應用中的研究。

       

背景信息

The BUD31 antibody is a valuable tool for studying the molecular role of the BUD31 protein, a conserved eukaryotic factor implicated in pre-mRNA splicing and cell cycle regulation. Originally identified in *Saccharomyces cerevisiae* for its role in bud-site selection, BUD31 is now recognized as a core component of the spliceosome, the macromolecular complex responsible for removing introns from precursor mRNA. In humans, BUD31 (also called CCDC51 or LUC7L3) interacts with spliceosomal proteins like SF3B1 and PRPF19. contributing to spliceosome assembly and catalytic activation. Its involvement in mRNA processing links it to diverse cellular processes, including transcription, DNA repair, and apoptosis. Dysregulation of BUD31 has been associated with cancers, neurological disorders, and developmental defects, highlighting its biological significance.

BUD31 antibodies are commonly raised against specific epitopes of the human or murine BUD31 protein and are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and protein interactions. These antibodies aid in exploring BUD31's role in splicing fidelity, its potential as a biomarker in diseases, and its response to splicing-modulating therapies. Validation for specificity and cross-reactivity is critical due to structural similarities among spliceosomal components. Host species (e.g., rabbit, mouse) and clonality (monoclonal/polyclonal) vary depending on application needs.

       
關鍵字: BUD31抗體;BUD31;BUD31 Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學,細胞生物學 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

BUD31抗體—艾普蒂相關廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
¥960.00
VIP10年
北京索萊寶科技有限公司
2025-08-15
¥1950
VIP3年
上海滬震實業(yè)有限公司
2025-08-15
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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