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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P10561(KPNA6 Antibody) at dilution 1/110. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10561(KPNA6 Antibody) at dilution 1/110. (Original magnification: ×200)    

  
  

The KPNA6 antibody is a crucial tool for studying the function and expression of Karyopherin alpha 6 (KPNA6), a member of the importin-α family involved in nucleocytoplasmic transport. KPNA6. encoded by the *KPNA6* gene, facilitates protein import into the nucleus by binding to cargo proteins containing classical nuclear localization signals (NLS) and interacting with importin-β1 (KPNB1) to mediate translocation through nuclear pores. This protein is part of a larger family with seven isoforms (KPNA1–7) in humans, each exhibiting tissue-specific expression and substrate preferences. KPNA6 is particularly noted for its role in development, immune regulation, and disease processes, including viral infections and cancer.

Antibodies targeting KPNA6 are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect its expression, subcellular localization, and interactions. These antibodies aid in elucidating KPNA6's involvement in cellular pathways, such as its potential dysregulation in tumors or its interaction with viral proteins that hijack nuclear import machinery. Validation of KPNA6 antibodies typically includes specificity checks using knockout cell lines or siRNA knockdown to ensure minimal cross-reactivity with other KPNA isoforms. High-quality antibodies are essential for reliable research, as aberrant KPNA6 expression has been linked to cancer progression, making it a biomarker candidate. Researchers prioritize antibodies with confirmed reactivity across human and model organisms to support translational studies.