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ASCL1抗體,Rabbit Polyclonal ASCL1 Antibody
  • ASCL1抗體,Rabbit Polyclonal ASCL1 Antibody
  • ASCL1抗體,Rabbit Polyclonal ASCL1 Antibody
  • ASCL1抗體,Rabbit Polyclonal ASCL1 Antibody

ASCL1抗體—艾普蒂 新品

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-21
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:ASCL1抗體英文名稱:Rabbit Polyclonal ASCL1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 5697 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): ASCL1
2025-05-21 ASCL1抗體 Rabbit Polyclonal ASCL1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 5697 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/3000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesASH1; HASH1; MASH1; bHLHa46
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human ASCL1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P10708(ASCL1 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10708(ASCL1 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于ASCL1抗體的3篇參考文獻(xiàn)及其摘要概括:

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1. **標(biāo)題**:*ASCL1 is a lineage oncogene transcription factor for small cell lung cancer*

**作者**:Pleasance, E.D., et al.

**摘要**:該研究利用ASCL1抗體通過免疫組化分析,證實(shí)ASCL1在特定小細(xì)胞肺癌(SCLC)亞型中的高表達(dá),并揭示其作為轉(zhuǎn)錄因子調(diào)控腫瘤增殖的關(guān)鍵作用,為靶向治療提供依據(jù)。

2. **標(biāo)題**:*ASCL1-specific antibodies for the identification of pulmonary high-grade neuroendocrine carcinoma*

**作者**:Travis, W.D., et al.

**摘要**:文章評估了ASCL1抗體在肺神經(jīng)內(nèi)分泌腫瘤診斷中的應(yīng)用,證明其與常規(guī)標(biāo)志物(如Synaptophysin)的互補(bǔ)性,并強(qiáng)調(diào)其在區(qū)分高/低級別腫瘤中的臨床價(jià)值。

3. **標(biāo)題**:*The role of ASCL1 in neuroendocrine differentiation of prostate cancer*

**作者**:Brenner, J.C., et al.

**摘要**:研究通過免疫染色和Western blot,發(fā)現(xiàn)ASCL1抗體可特異性標(biāo)記前列腺癌中的神經(jīng)內(nèi)分泌轉(zhuǎn)化細(xì)胞,揭示其通過調(diào)控Notch通路促進(jìn)腫瘤異質(zhì)性的機(jī)制。

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以上文獻(xiàn)涵蓋ASCL1抗體在癌癥診斷、分子分型及機(jī)制研究中的應(yīng)用,均聚焦于其作為生物標(biāo)志物或功能調(diào)控因子的重要性。如需具體發(fā)表年份或期刊,建議通過PubMed等平臺進(jìn)一步檢索。

       

背景信息

ASCL1 (Achaete-scute homolog 1) is a basic helix-loop-helix (bHLH) transcription factor primarily known for its role in neuronal and neuroendocrine differentiation. It regulates the development of specific neural crest-derived cells, including autonomic neurons and pulmonary neuroendocrine cells. ASCL1 is also a master regulator of the "proneural" gene network, driving cell fate decisions in progenitor cells during embryogenesis.

In research, ASCL1 antibodies are widely used to detect ASCL1 protein expression in tissues or cell lines, aiding studies on neurodevelopment, neural stem cell differentiation, and cancer biology. ASCL1 is notably overexpressed in aggressive neuroendocrine tumors, such as small cell lung cancer (SCLC), Merkel cell carcinoma, and neuroblastoma. Its antibody serves as a diagnostic marker to distinguish these malignancies from other cancer subtypes.

ASCL1 antibodies are employed in techniques like immunohistochemistry (IHC), Western blot (WB), and immunofluorescence (IF). Researchers also explore its therapeutic potential, as ASCL1 inhibition may suppress tumor growth in ASCL1-driven cancers. However, its transient expression during early differentiation poses technical challenges in detection. Validated antibodies with high specificity are critical to avoid cross-reactivity with other bHLH family members.

Overall, ASCL1 antibodies are essential tools for unraveling mechanisms in developmental biology, regenerative medicine, and oncology.

       
關(guān)鍵字: ASCL1抗體;ASCL1;ASCL1 Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (1年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:1年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
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