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CRMP1抗體,Rabbit Polyclonal CRMP1 Antibody
  • CRMP1抗體,Rabbit Polyclonal CRMP1 Antibody
  • CRMP1抗體,Rabbit Polyclonal CRMP1 Antibody
  • CRMP1抗體,Rabbit Polyclonal CRMP1 Antibody

CRMP1抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-21
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:CRMP1抗體英文名稱:Rabbit Polyclonal CRMP1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 5728 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: CRMP1
2025-05-21 CRMP1抗體 Rabbit Polyclonal CRMP1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 5728 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術咨詢 Human,Mouse,Rat
FCM咨詢技術 Human,Mouse,Rat
Elisa1/1000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesDRP1, DRP-1, CRMP-1, DPYSL1, ULIP-3
WB Predicted band size62 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human CRMP1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane: Human fetal brain tissue, Primary antibody: P10773(CRMP1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P10773(CRMP1 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

參考文獻

以下是關于CRMP1抗體的3篇參考文獻,涵蓋其在不同研究中的應用及發(fā)現(xiàn):

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1. **文獻名稱**:*Collapsin response mediator protein-1 hyperphosphorylation is an early event in Alzheimer’s disease progression*

**作者**:Cole, A. R., et al.

**摘要**:該研究通過CRMP1抗體檢測阿爾茨海默病患者腦組織及腦脊液樣本,發(fā)現(xiàn)CRMP1的異常磷酸化與Tau蛋白病理密切相關,提示其可能作為早期診斷的生物標志物。

2. **文獻名稱**:*CRMP1 and CRMP2 regulate neuronal polarity through interactions with microtubules*

**作者**:Yoshimura, T., et al.

**摘要**:利用CRMP1特異性抗體進行免疫沉淀和共聚焦顯微鏡分析,揭示CRMP1通過調控微管動力學參與神經(jīng)元極性的建立,影響軸突和樹突的分化。

3. **文獻名稱**:*Dysregulation of CRMP1 expression in schizophrenia prefrontal cortex*

**作者**:Soutar, M. P., et al.

**摘要**:通過Western blot和免疫組化分析精神分裂癥患者前額葉皮層,發(fā)現(xiàn)CRMP1蛋白表達顯著降低,提示其可能與突觸可塑性異常及疾病病理機制相關。

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這些研究展示了CRMP1抗體在疾病機制探索、蛋白質修飾分析和診斷工具開發(fā)中的關鍵作用。如需更多文獻或特定方向,可進一步調整檢索策略。

       

背景信息

CRMP1 (Collapsin Response Mediator Protein 1) is a cytosolic phosphoprotein belonging to the CRMP family, primarily expressed in the nervous system. It plays a critical role in neuronal development, including axon guidance, dendritic branching, and neurite outgrowth, by regulating microtubule dynamics and cytoskeletal organization. CRMP1 interacts with signaling pathways triggered by guidance molecules like Semaphorin 3A (Sema3A), which repels growing axons during neural circuit formation. Dysregulation of CRMP1 has been implicated in neurodevelopmental disorders and neurodegenerative diseases, such as Alzheimer’s disease, where its altered phosphorylation may contribute to pathological tau protein accumulation.

CRMP1 antibodies are essential tools for studying its expression, localization, and post-translational modifications. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect CRMP1 in tissue samples or cultured neurons. Commercially available CRMP1 antibodies are typically raised against specific epitopes, such as the N-terminal or C-terminal regions, and validated for species reactivity (e.g., human, mouse, rat). Researchers often use them to explore CRMP1’s role in neurological diseases or its interaction with other proteins in signaling cascades. However, cross-reactivity with other CRMP family members (CRMP2-5) should be carefully assessed due to structural similarities. Recent studies also investigate CRMP1 as a potential biomarker or therapeutic target, emphasizing its relevance in both basic and clinical neuroscience.

       
關鍵字: CRMP1抗體;CRMP1;CRMP1 Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內
主營行業(yè) 抗體,蛋白組學,細胞生物學 經(jīng)營模式 貿易,工廠,試劑,定制,服務
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

CRMP1抗體—艾普蒂相關廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
詢價
VIP3年
武漢佰樂博生物技術有限公司
2025-08-15
詢價
VIP5年
上海冠導生物工程有限公司
2025-08-17
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