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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of HDAC11 expression in (1) Jurkat cell lysate;(2) MCF7 cell lysate.    

  
  

Histone deacetylase 11 (HDAC11) is a member of the histone deacetylase family, enzymes that regulate gene expression by removing acetyl groups from histones, leading to chromatin condensation and transcriptional repression. As the sole member of the class IV HDAC subfamily, HDAC11 is evolutionarily distinct from other HDACs and is the most recently identified isoform. It is widely expressed in tissues, with notable roles in immune regulation, cellular metabolism, and cell cycle progression. HDAC11 has garnered attention for its dual enzymatic activity, acting on both histone and non-histone substrates, and its involvement in immune tolerance, T-cell activation, and tumor microenvironment modulation.

HDAC11-specific antibodies are critical tools for studying its expression, localization, and function in various biological contexts. These antibodies enable techniques like Western blotting, immunohistochemistry, immunofluorescence, and chromatin immunoprecipitation (ChIP). Researchers use them to investigate HDAC11's role in diseases such as cancer, neurodegenerative disorders, and autoimmune conditions. Validating HDAC11 antibodies is essential due to potential cross-reactivity with other HDACs, emphasizing the need for rigorous specificity tests (e.g., knockdown controls). Recent studies highlight HDAC11 as a potential therapeutic target, driving demand for reliable antibodies to explore its mechanisms in epigenetic regulation and disease pathways.