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MFSD2A抗體,Rabbit Polyclonal MFSD2A Antibody
  • MFSD2A抗體,Rabbit Polyclonal MFSD2A Antibody
  • MFSD2A抗體,Rabbit Polyclonal MFSD2A Antibody
  • MFSD2A抗體,Rabbit Polyclonal MFSD2A Antibody

MFSD2A抗體;MFSD2A Antibody—艾普蒂 新品

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-26
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:MFSD2A抗體英文名稱:Rabbit Polyclonal MFSD2A Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 6359 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): MFSD2A
2025-05-26 MFSD2A抗體 Rabbit Polyclonal MFSD2A Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 6359 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesMFSD2
WB Predicted band size60 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human MFSD2A
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Human thyroid cancer tissue, mouse liver tissue, human fetal liver tissue, A549 cells, 293T cells, Primary antibody: P11939(MFSD2A Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11939(MFSD2A Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P11939(MFSD2A Antibody) at dilution 1/25. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是3篇關(guān)于MFSD2A抗體的重要文獻(xiàn)概覽:

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1. **文獻(xiàn)名稱**:Mfsd2a is critical for the formation and function of the blood-brain barrier

**作者**:Ben-Zvi A, et al.

**摘要**:首次揭示MFSD2A通過轉(zhuǎn)運(yùn)omega-3脂肪酸DHA維持血腦屏障完整性,其抗體被用于驗(yàn)證內(nèi)皮細(xì)胞特異性表達(dá)及功能缺失模型中的蛋白定位變化。

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2. **文獻(xiàn)名稱**:Mutations in MFSD2A, encoding a lysolipid transporter for docosahexaenoic acid, cause microcephaly and intellectual disability

**作者**:Guemez-Gamboa A, et al.

**摘要**:通過患者基因測(cè)序發(fā)現(xiàn)MFSD2A突變導(dǎo)致小頭畸形,利用特異性抗體證實(shí)突變?cè)斐傻鞍妆磉_(dá)異常,揭示其在神經(jīng)發(fā)育中脂質(zhì)轉(zhuǎn)運(yùn)的關(guān)鍵作用。

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3. **文獻(xiàn)名稱**:Structural basis of omega-3 fatty acid transport across the blood-brain barrier

**作者**:Chan JP, et al.

**摘要**:通過冷凍電鏡解析MFSD2A蛋白結(jié)構(gòu),抗體被用于實(shí)驗(yàn)驗(yàn)證其與脂質(zhì)配體的結(jié)合模式,闡明DHA跨血腦屏障轉(zhuǎn)運(yùn)的分子機(jī)制。

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**備注**:以上文獻(xiàn)均發(fā)表于《Nature》或《Cell》等高影響力期刊,建議通過PubMed/Google Scholar輸入標(biāo)題或作者名獲取全文。若需實(shí)驗(yàn)用抗體信息,可參考文內(nèi)Methods部分或商業(yè)抗體平臺(tái)(如Abcam/Santa Cruz)的產(chǎn)品引用文獻(xiàn)。

       

背景信息

The MFSD2A (Major Facilitator Superfamily Domain Containing 2A) antibody is a critical tool for studying the function and expression of the MFSD2A protein, a transmembrane transporter belonging to the major facilitator superfamily. MFSD2A is primarily expressed in the endothelium of the blood-brain barrier (BBB) and plays a vital role in transporting essential lipids, such as docosahexaenoic acid (DHA), into the brain. It is also implicated in maintaining BBB integrity by regulating vesicular transcytosis. Dysregulation of MFSD2A has been linked to neurological disorders, including cognitive deficits and neurodevelopmental impairments.

The antibody enables researchers to detect MFSD2A in various experimental settings, such as Western blotting, immunohistochemistry, and flow cytometry, aiding in the investigation of its tissue distribution, expression levels, and interactions. Studies using MFSD2A antibodies have revealed its reduced expression in aging brains and certain disease models, such as Alzheimer’s disease and stroke. Additionally, genetic knockout models validated by antibody-based assays highlight MFSD2A’s role in lipid homeostasis and neuroprotection.

Understanding MFSD2A’s mechanisms through antibody-mediated research holds promise for developing therapies targeting BBB dysfunction or lipid metabolism disorders. Its specificity and reliability make it indispensable for both basic and translational neuroscience studies.

       
關(guān)鍵字: MFSD2A抗體;MFSD2A;MFSD2A Antibody;

公司簡(jiǎn)介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營(yíng)行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

MFSD2A抗體;MFSD2A Antibody—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥1098
VIP3年
上海滬震實(shí)業(yè)有限公司
2025-08-15
¥1600.00
VIP10年
北京索萊寶科技有限公司
2025-08-15
詢價(jià)
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
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