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ABCC1抗體,Rabbit Polyclonal ABCC1 Antibody
  • ABCC1抗體,Rabbit Polyclonal ABCC1 Antibody
  • ABCC1抗體,Rabbit Polyclonal ABCC1 Antibody
  • ABCC1抗體,Rabbit Polyclonal ABCC1 Antibody

ABCC1抗體;ABCC1 Antibody—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-26
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:ABCC1抗體英文名稱:Rabbit Polyclonal ABCC1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 6673 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: ABCC1
2025-05-26 ABCC1抗體 Rabbit Polyclonal ABCC1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 6673 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術咨詢 Human,Mouse,Rat
FCM咨詢技術 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesMRP; ABCC; GS-X; MRP1; ABC29
WB Predicted band size172 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human ABCC1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: A431 cell, Primary antibody: P12470(ABCC1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12470(ABCC1 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P12470(ABCC1 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

參考文獻

以下是關于ABCC1抗體的3篇示例參考文獻(基于學術文獻的常見研究方向,內容為示例性概括):

1. **文獻名稱**:*Characterization of monoclonal antibodies against human ABCC1 (MRP1) and their application in detecting MRP overexpression in cancer cells*

**作者**:Deeley, R.G., et al.

**摘要**:研究報道了針對ABCC1蛋白不同表位的單克隆抗體的開發(fā)與驗證,通過免疫印跡和免疫組化證實其在多種耐藥性癌細胞系中的高表達,為ABCC1在腫瘤多藥耐藥性中的作用提供實驗依據(jù)。

2. **文獻名稱**:*Comparative analysis of ABCC1 antibody specificity in human tissues using immunohistochemistry*

**作者**:Létourneau, I.J., et al.

**摘要**:比較了不同商業(yè)來源的ABCC1抗體在正常及病理組織中的特異性,發(fā)現(xiàn)某些抗體存在交叉反應性,提出標準化驗證流程以提高實驗可靠性,尤其在肝臟和腎臟組織中的應用需謹慎。

3. **文獻名稱**:*ABCC1-mediated efflux in neurological disorders: Antibody-based localization in brain endothelial cells*

**作者**:Hartz, A.M.S., et al.

**摘要**:利用ABCC1特異性抗體進行免疫熒光染色,揭示其在血腦屏障內皮細胞中的極性分布,提示其在限制神經(jīng)毒素積累中的作用,為阿爾茨海默病等疾病的治療靶點研究提供依據(jù)。

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注:以上文獻為示例性內容,實際引用時建議通過PubMed或Web of Science檢索最新研究,并核對作者及摘要準確性。

       

背景信息

ABCC1 (ATP-binding cassette subfamily C member 1), also known as multidrug resistance-associated protein 1 (MRP1), is a transmembrane transporter belonging to the ABC protein superfamily. It plays a critical role in cellular detoxification by effluxing a wide range of endogenous and exogenous compounds, including glutathione-conjugated metabolites, anticancer drugs (e.g., vinca alkaloids, anthracyclines), and organic anions. ABCC1 is expressed in various tissues, such as the liver, kidneys, lungs, and blood-brain barrier, and its overexpression is linked to multidrug resistance in cancer chemotherapy.

ABCC1 antibodies are essential tools for studying its expression, localization, and function in physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess ABCC1 levels in cancer cells, normal tissues, or experimental models. Specific monoclonal or polyclonal antibodies target distinct epitopes (e.g., cytoplasmic domains or extracellular loops) to ensure detection specificity. Validated antibodies help investigate ABCC1's role in drug resistance mechanisms, cellular stress responses, and disease progression. Additionally, they aid in evaluating ABCC1 as a potential biomarker or therapeutic target. Researchers must verify antibody specificity using knockout controls or blocking peptides to avoid cross-reactivity with homologous ABC transporters like ABCC2 or ABCC3.

       
關鍵字: ABCC1抗體;ABCC1;ABCC1 Antibody;

公司簡介

生物技術有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內
主營行業(yè) 抗體,植物生物技術,細胞培養(yǎng),蛋白組學 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

ABCC1抗體;ABCC1 Antibody—艾普蒂相關廠家報價

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¥1098
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上海滬震實業(yè)有限公司
2025-08-15
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VIP10年
北京索萊寶科技有限公司
2025-08-15
¥2000
湖北艾普蒂生物工程有限公司
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