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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P12586(PEG3 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P12586(PEG3 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

The PEG3 (Paternally Expressed Gene 3) antibody is a research tool used to detect the PEG3 protein, a member of the zinc finger protein family encoded by an imprinted gene located on human chromosome 19q13.4. PEG3 is maternally silenced and paternally expressed, playing critical roles in embryonic development, cell proliferation, and apoptosis regulation. It is implicated in neural system development, placental function, and genomic imprinting mechanisms. Dysregulation of PEG3 has been associated with cancers (e.g., breast, ovarian), neurological disorders, and imprinting-related syndromes like Schaaf-Yang syndrome.

The PEG3 antibody enables researchers to study the protein's expression patterns, subcellular localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It is essential for investigating PEG3's tumor-suppressive functions, epigenetic regulation, and involvement in autophagy or oxidative stress pathways. Commercially available PEG3 antibodies are typically raised in rabbits or mice, validated for specificity using knockout controls or siRNA. Challenges include cross-reactivity with homologous proteins (e.g., PEG1. PEG5) and variability in tissue-specific isoforms. Recent studies leverage PEG3 antibodies to explore its role in metabolic reprogramming, stem cell differentiation, and as a potential biomarker for cancer prognosis. Proper validation and application-specific optimization remain crucial for reliable experimental outcomes.