**Background of MAST4 Antibody**
MAST4 (Microtubule-Associated Serine/Threonine Kinase 4) is a member of the MAST kinase family, which plays roles in cellular processes such as neuronal development, synaptic plasticity, and signal transduction. The MAST4 protein contains a kinase domain, a PDZ domain, and a conserved region of unknown function, enabling interactions with cytoskeletal components, membrane proteins, and signaling molecules. MAST4 is highly expressed in the brain, particularly in regions like the hippocampus and cortex, suggesting its importance in neurodevelopment and cognitive function.
MAST4 antibodies are immunological tools designed to detect and study the expression, localization, and function of the MAST4 protein. These antibodies are widely used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to investigate MAST4's role in health and disease. Research has linked MAST4 dysregulation to neurological disorders, including Alzheimer’s disease, and cancers such as glioblastoma and breast cancer, where it may influence tumor progression or drug resistance.
Commercial MAST4 antibodies are typically validated for specificity and sensitivity across applications, aiding in both basic research and clinical studies. Their development has advanced understanding of MAST4’s molecular mechanisms, though its full biological significance remains under exploration.