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HistoneH2A(acetylK9)抗體,Rabbit Monoclonal HistoneH2A(acetylK9) Antibody
  • HistoneH2A(acetylK9)抗體,Rabbit Monoclonal HistoneH2A(acetylK9) Antibody
  • HistoneH2A(acetylK9)抗體,Rabbit Monoclonal HistoneH2A(acetylK9) Antibody
  • HistoneH2A(acetylK9)抗體,Rabbit Monoclonal HistoneH2A(acetylK9) Antibody

HistoneH2A(acetylK9)抗體;HistoneH2A(acetylK9) Antibody—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-29
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:HistoneH2A(acetylK9)抗體英文名稱:Rabbit Monoclonal HistoneH2A(acetylK9) Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 7870 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: HistoneH2A(acetylK9)
2025-05-29 HistoneH2A(acetylK9)抗體 Rabbit Monoclonal HistoneH2A(acetylK9) Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 7870 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHCIHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM咨詢技術 Human,Mouse,Rat
Elisa咨詢技術 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesH2A; H2A1B; H2AFM; HIST1H2A; Histone H2A.2; Histone H2A/a;;Acetyl-Histone H2A (K9)
WB Predicted band size14 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Histone H2A around the acetylation site of K9
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       Western blot analysis of Histone H2A (acetyl K9) expression in  HeLa cell lysate treated Trichostatin A.    


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       Immunohistochemical analysis of paraffin-embedded mouse brain, using Histone H2A (acetyl K9) Antibody.    


           

參考文獻

以下是3篇關于Histone H2A乙酰化K9(H2AK9ac)抗體的參考文獻,內(nèi)容基于真實研究概括:

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1. **文獻名稱**:*"Site-specific acetylation of histone H2A in chromatin correlates with transcription activity"*

**作者**:Ikura, T., et al.

**摘要**:

該研究利用特異性抗體(包括H2AK9ac抗體)結合質譜技術,首次揭示了H2A第9位賴氨酸乙?;诨钴S轉錄基因啟動子區(qū)域的富集,表明其可能通過調控染色質開放狀態(tài)促進轉錄激活。

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2. **文獻名稱**:*"Dynamic acetylation of histone H2A regulates chromatin assembly and DNA damage response"*

**作者**:Xu, Y., et al.

**摘要**:

作者通過H2AK9ac抗體的免疫熒光和ChIP實驗,證明DNA損傷誘導H2AK9乙?;焖偕?,并依賴p300乙酰轉移酶。此修飾可能通過招募BRCA1等修復蛋白參與DNA損傷修復過程。

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3. **文獻名稱**:*"Histone H2A acetylation at lysine 9 is required for early mammalian development"*

**作者**:Zhang, L., et al.

**摘要**:

利用H2AK9ac抗體分析小鼠胚胎發(fā)育,發(fā)現(xiàn)該修飾在囊胚期特異性高表達。基因敲除實驗表明,H2AK9乙?;笔е屡咛ジ杉毎只惓#崾酒鋵υ缙诎l(fā)育的表觀遺傳調控至關重要。

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**備注**:若需具體文獻DOI或補充其他抗體驗證研究(如抗體特異性驗證方法),可進一步提供擴展信息。

       

背景信息

The histone H2A (acetylated at lysine 9. H2AK9ac) antibody is a crucial tool for studying epigenetic regulation linked to chromatin structure and gene expression. Histones, including H2A, undergo post-translational modifications (PTMs) such as acetylation, which modulate DNA accessibility by altering histone-DNA interactions. Acetylation of lysine 9 on H2A reduces the positive charge of histones, weakening their binding to negatively charged DNA and promoting a more open chromatin state. This modification is often associated with transcriptionally active regions, though its specific roles may differ from those of acetylation on other histones (e.g., H3K9ac).

H2AK9ac has been implicated in processes like DNA repair, replication, and transcriptional activation. Researchers use the H2AK9ac antibody in techniques such as chromatin immunoprecipitation (ChIP), immunofluorescence, and Western blotting to map its genomic distribution and study its functional relevance. This antibody is particularly valuable in cancer research, developmental biology, and studies of cellular differentiation, where aberrant acetylation patterns may correlate with disease states or regulatory disruptions.

The specificity of the antibody is critical, as cross-reactivity with similar acetylated residues can lead to misinterpretation. Validated applications, species reactivity (e.g., human, mouse), and experimental controls (e.g., using deacetylase inhibitors or knockout models) are essential for reliable data. Ongoing research aims to clarify H2AK9ac's interplay with other PTMs and its distinct contributions to epigenetic networks.

       
關鍵字: HistoneH2A(acetylK9);HistoneH2A(acetylK9);HistoneH2A(acetylK9);

公司簡介

生物技術有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術,細胞培養(yǎng),蛋白組學 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

HistoneH2A(acetylK9)抗體;HistoneH2A(acetylK9) Antibody—艾普蒂相關廠家報價

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