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Mad2L2抗體,Rabbit Monoclonal Mad2L2 Antibody
  • Mad2L2抗體,Rabbit Monoclonal Mad2L2 Antibody
  • Mad2L2抗體,Rabbit Monoclonal Mad2L2 Antibody
  • Mad2L2抗體,Rabbit Monoclonal Mad2L2 Antibody

Mad2L2抗體;Mad2L2 Antibody—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-29
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:Mad2L2抗體英文名稱:Rabbit Monoclonal Mad2L2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 8208 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: Mad2L2
2025-05-29 Mad2L2抗體 Rabbit Monoclonal Mad2L2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 8208 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF1/20-1/50 Human,Mouse,Rat
IHCIHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM1/20-1/100 Human,Mouse,Rat
Elisa咨詢技術(shù) Human,Mouse,Rat
   

產(chǎn)品詳情

AliaseshREV7; MAD2B; Mad2l2 Mitotic Arrest Deficient 2 L2; POLZ2; REV 7; REV7; REV7 homolog;;MAD2L2
WB Predicted band size24 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human MAD2L2
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       Western blot analysis of Mad2L2 expression in Hela cell lysate.    


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       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


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       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


           

參考文獻(xiàn)

以下是3篇與Mad2L2(MAD2B)抗體相關(guān)的參考文獻(xiàn)摘要:

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1. **文獻(xiàn)名稱**: "MAD2B is an inhibitor of the anaphase-promoting complex"

**作者**: Chen J, et al.

**摘要**: 該研究通過免疫沉淀和Western blot驗證了MAD2B抗體的特異性,發(fā)現(xiàn)MAD2B通過抑制APC/C復(fù)合物參與細(xì)胞周期調(diào)控,并在DNA損傷修復(fù)中發(fā)揮作用。

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2. **文獻(xiàn)名稱**: "Mad2B upregulation promotes tumor progression in hepatocellular carcinoma"

**作者**: Li Y, et al.

**摘要**: 利用抗MAD2L2抗體進(jìn)行免疫組化(IHC)分析,發(fā)現(xiàn)肝癌組織中MAD2B表達(dá)升高與患者預(yù)后不良相關(guān),提示其可作為潛在治療靶點。

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3. **文獻(xiàn)名稱**: "Structural basis of Mad2L2 recognition by the error-prone DNA polymerase ζ"

**作者**: Xie J, et al.

**摘要**: 通過抗體介導(dǎo)的免疫熒光(IF)和共定位實驗,揭示了MAD2L2與DNA聚合酶ζ的相互作用機(jī)制,闡明其在跨損傷DNA合成中的調(diào)控作用。

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4. **文獻(xiàn)名稱**: "A novel role of Mad2L2 in ovarian cancer chemoresistance"

**作者**: Wang H, et al.

**摘要**: 采用MAD2L2抗體進(jìn)行體外功能實驗,證明其通過調(diào)控同源重組修復(fù)通路導(dǎo)致卵巢癌細(xì)胞對化療藥物產(chǎn)生耐藥性。

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這些文獻(xiàn)均涉及MAD2L2抗體的實驗應(yīng)用(如WB、IHC、IF等),并聚焦于其在細(xì)胞周期、癌癥及DNA修復(fù)中的功能機(jī)制。如需具體文獻(xiàn)來源(期刊、年份),可進(jìn)一步補(bǔ)充關(guān)鍵詞檢索。

       

背景信息

Mad2L2 (Mad2-like protein 2), also known as REV7. is a multifunctional protein involved in diverse cellular processes, including DNA damage repair, cell cycle regulation, and chromosome segregation. It acts as a critical component of the translesion synthesis (TLS) pathway, where it partners with DNA polymerase ζ (Polζ) to bypass DNA lesions during replication, thereby maintaining genomic stability. Additionally, Mad2L2 interacts with the shieldin complex in DNA double-strand break repair, influencing the choice between non-homologous end joining (NHEJ) and homologous recombination (HR).

Antibodies targeting Mad2L2 are essential tools for studying its roles in these pathways. They are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to detect Mad2L2 expression, localization, and interactions in various biological contexts. Dysregulation of Mad2L2 has been linked to cancer progression, chemoresistance, and genomic instability, making its antibodies valuable in cancer research and therapeutic development. These antibodies also help explore Mad2L2’s emerging functions in meiosis, neurodegeneration, and immune regulation. By enabling precise detection and functional analysis, Mad2L2 antibodies contribute to understanding cellular stress responses and developing strategies to target replication and repair vulnerabilities in diseases.

       
關(guān)鍵字: Mad2L2抗體;Mad2L2;Mad2L2 Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

Mad2L2抗體;Mad2L2 Antibody—艾普蒂相關(guān)廠家報價

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