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     Western blot analysis of SLC27A4 / FATP4 expression in  (1) HeLa cell lysate; (2) Mouse kidney lysate.    

  
  

The solute carrier family 27 member 4 (SLC27A4), also known as fatty acid transport protein 4 (FATP4), is a transmembrane protein critical for cellular uptake and metabolism of long-chain fatty acids. It is highly expressed in tissues with active lipid metabolism, including the small intestine, skin, and adipose tissue. FATP4 functions both as a fatty acid transporter and an acyl-CoA synthetase, facilitating fatty acid internalization and activation for metabolic pathways like triglyceride synthesis or β-oxidation. Research links FATP4 to insulin resistance, obesity, and lipid-related disorders, with mutations associated with ichthyosis prematurity syndrome (IPS) and disrupted epidermal lipid homeostasis.

Antibodies targeting SLC27A4/FATP4 are essential tools for studying its expression, localization, and functional roles. They are widely used in Western blotting, immunohistochemistry, and immunofluorescence to investigate tissue-specific distribution or alterations under metabolic conditions. Such antibodies also aid in exploring FATP4’s involvement in diseases; for example, reduced FATP4 levels correlate with impaired lipid absorption in intestinal models, while skin-specific knockout studies highlight its role in maintaining epidermal barrier integrity. Additionally, therapeutic research leverages these antibodies to validate targeting strategies for metabolic syndromes or genetic lipid disorders. Validation of antibody specificity remains crucial due to structural similarities among FATPs.