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     Western blot analysis of GRSF1 expression in 293 cell lysate.    

  
  

The GRSF1 (G-rich RNA sequence binding factor 1) antibody is a tool used to detect and study the GRSF1 protein, a member of the RNA-binding protein family involved in post-transcriptional gene regulation. GRSF1 is characterized by three RNA recognition motifs (RRMs) that enable binding to G-rich regions in RNA, influencing mRNA stability, transport, and translation. It plays critical roles in mitochondrial RNA metabolism, viral replication (e.g., influenza A virus), and cellular stress responses.

Research highlights GRSF1's involvement in mitochondrial gene expression by interacting with mitochondrial transcripts and ribosomal components. It also modulates antiviral immune responses by regulating viral RNA processing. Dysregulation of GRSF1 has been linked to cancers, where it may act as an oncogene by promoting cell proliferation or survival.

The GRSF1 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and interactions. Its development has advanced studies on RNA-protein dynamics, mitochondrial dysfunction, and disease mechanisms. Commercial antibodies are typically validated for specificity across human, mouse, and rat samples, supporting cross-species research. Understanding GRSF1's functions via antibody-based assays continues to shed light on its regulatory networks in health and disease.