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     Western blot analysis of TRBP expression in Jurkat cell lysate.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

TRBP (TAR RNA-binding protein), also known as TARBP2. is a double-stranded RNA-binding protein encoded by the TARBP2 gene. It plays critical roles in RNA interference (RNAi) pathways, microRNA (miRNA) processing, and post-transcriptional gene regulation. TRBP interacts with Dicer, a key enzyme in the RNAi machinery, to facilitate the processing of precursor miRNAs into mature miRNAs, which are essential for gene silencing. Additionally, TRBP is involved in HIV-1 replication by binding to the viral TAR RNA element, modulating viral transcription and evasion of host immune responses.

TRBP antibodies are essential tools for studying its molecular functions, protein-protein interactions, and subcellular localization. These antibodies are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect TRBP expression in various cell types and tissues. Dysregulation of TRBP has been linked to cancers, neurological disorders, and viral infections, making its detection crucial for understanding disease mechanisms. For instance, altered TRBP levels are observed in glioblastoma, colorectal cancer, and HIV-associated pathologies. Researchers also utilize TRBP antibodies to explore its role in stress granule formation, autophagy, and antiviral defense pathways. Commercial TRBP antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated knockdown. Their applications extend to diagnostic research and therapeutic development, particularly in targeting RNAi pathways or viral replication processes.