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     Western blot analysis of PIST expression in A375 cell lysate.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

PIST (PDZ domain protein interacting specifically with TC10), also known as GOPC (Golgi-associated PDZ and coiled-coil motif-containing protein), is a multidomain scaffolding protein involved in intracellular trafficking and membrane protein organization. It contains a PDZ domain and a coiled-coil motif, enabling interactions with various partners, including receptors, channels, and trafficking regulators. Initially identified through its interaction with TC10. a Rho GTPase, PIST localizes to the Golgi apparatus and participates in vesicle transport, protein sorting, and synaptic regulation.

Studies highlight its role in neuronal and epithelial cell function, influencing processes like neurotransmitter receptor trafficking and tight junction formation. Dysregulation of PIST is linked to pathologies such as cancer, where it may modulate oncogenic signaling or metastasis, and neurological disorders, potentially affecting synaptic plasticity.

PIST antibodies are essential tools for investigating these mechanisms. They enable detection and localization of PIST in cells and tissues via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Such antibodies aid in exploring PIST's interaction networks, post-translational modifications, and disease-related alterations. Research using PIST antibodies continues to uncover its therapeutic potential, particularly in targeting trafficking pathways implicated in cancer or neurodegeneration.