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Neurocan抗體,Rabbit Monoclonal Neurocan Antibody
  • Neurocan抗體,Rabbit Monoclonal Neurocan Antibody
  • Neurocan抗體,Rabbit Monoclonal Neurocan Antibody
  • Neurocan抗體,Rabbit Monoclonal Neurocan Antibody

Neurocan抗體;Neurocan Antibody—艾普蒂 新品

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-30
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:Neurocan抗體英文名稱:Rabbit Monoclonal Neurocan Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 8742 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: Neurocan
2025-05-30 Neurocan抗體 Rabbit Monoclonal Neurocan Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 8742 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF1/20-1/50 Human,Mouse,Rat
IHC1/100-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa咨詢技術(shù) Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesCspg3; Ncan; NEUR; Neurocan core protein;;Neurocan
WB Predicted band sizeCalculated MW: 143 kDa ; Observed MW: 130270 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human Neurocan
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

+ +

  •  

     

       Western blot analysis of Neurocan expression in Fetal brain cell lysate.    


  •  

     

       Immunoprecipitate (IP) analysis using the Antibody at 1:50 dilution. (wb at 1:3K dilution)    


           

參考文獻

以下是關(guān)于Neurocan抗體的3篇參考文獻及其摘要概括:

1. **文獻名稱**: "Purification and characterization of developmentally regulated chondroitin sulfate proteoglycans expressed in embryonic brain"

**作者**: Rauch U. et al.

**摘要**: 該研究純化了胚胎大鼠腦中的Neurocan蛋白,并制備了特異性抗體。通過免疫化學(xué)分析,揭示了Neurocan在神經(jīng)發(fā)育過程中的時空表達模式,證實其作為硫酸軟骨素蛋白聚糖在中樞神經(jīng)系統(tǒng)細胞黏附中的調(diào)控作用。

2. **文獻名稱**: "Neurocan is upregulated in injured brain and in cytokine-treated astrocytes"

**作者**: Asher R.A. et al.

**摘要**: 文章利用Neurocan抗體檢測其在腦損傷后的表達變化,發(fā)現(xiàn)Neurocan在膠質(zhì)瘢痕中顯著上調(diào),且炎性因子(如TGF-β)可誘導(dǎo)星形膠質(zhì)細胞分泌Neurocan,提示其參與抑制軸突再生。

3. **文獻名稱**: "The chondroitin sulfate proteoglycans neurocan and phosphacan are expressed by reactive astrocytes in the chronic CNS glial scar"

**作者**: Matsui F. et al.

**摘要**: 通過免疫組化結(jié)合Neurocan抗體,研究證明Neurocan在慢性膠質(zhì)瘢痕中由反應(yīng)性星形膠質(zhì)細胞持續(xù)表達,可能通過抑制神經(jīng)元突觸可塑性影響中樞神經(jīng)系統(tǒng)的修復(fù)。

4. **文獻名稱**: "Binding of tenascin-R and neurocan to phosphacan creates a ternary complex influencing neurite extension"

**作者**: Milev P. et al.

**摘要**: 研究利用Neurocan抗體探究其與tenascin-R、phosphacan的相互作用,發(fā)現(xiàn)三者形成的復(fù)合物可調(diào)節(jié)神經(jīng)元突觸生長,為Neurocan在神經(jīng)再生中的抑制機制提供了分子層面的解釋。

這些文獻均涉及Neurocan抗體的實驗應(yīng)用,涵蓋發(fā)育、損傷修復(fù)及分子機制等領(lǐng)域。

       

背景信息

Neurocan antibodies are essential tools in neuroscience research, specifically targeting neurocan, a chondroitin sulfate proteoglycan (CSPG) predominantly expressed in the central nervous system (CNS). Neurocan, a member of the lectican family, plays critical roles during brain development by regulating neuronal migration, axon guidance, and synaptic plasticity. It is highly abundant in the extracellular matrix (ECM) of developing brains but decreases in adulthood, though its expression can be upregulated following CNS injury or in neurodegenerative conditions like Alzheimer’s or Parkinson’s disease. Neurocan interacts with other ECM components and cell surface receptors, influencing cell adhesion and signaling pathways.

Antibodies against neurocan enable researchers to detect and study its spatial-temporal distribution, functional interactions, and involvement in pathological processes. They are widely used in techniques such as immunohistochemistry, Western blotting, and immunofluorescence to visualize neurocan in tissue sections or cultured cells. These antibodies have been instrumental in exploring neurocan’s dual role: while it inhibits axonal regeneration post-injury by creating a growth-restrictive environment, it also supports neuroprotection and ECM remodeling. Additionally, neurocan antibodies aid in investigating its potential as a biomarker for neurological disorders and in evaluating therapeutic strategies targeting CSPGs to enhance neural repair. Most neurocan antibodies are raised against specific epitopes in its core protein, ensuring specificity across species like humans, mice, and rats.

       
關(guān)鍵字: Neurocan抗體;Neurocan;Neurocan Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

Neurocan抗體;Neurocan Antibody—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
¥1098
VIP3年
上海滬震實業(yè)有限公司
2025-08-15
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費雪(杭州)醫(yī)學(xué)研究有限公司
2025-08-13
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