3-Isocyanatopropyltrimethoxysilane is colorless clear liquid. It is unique isocyanate functional silanes.3-Isocyanatopropyltrimethoxysilane uses and applications include: Used in the production of polymers which serve as binders in adhesives, sealants and coatings.

Using 3-Isocyanatopropyltrimethoxysilane to Decorate Graphene Oxide

The graphene oxide loaded with nano titanium dioxide (TiO2–GO) was synthesized through 3-isocyanatopropyltrimethoxysilane. Comparing to pristine particles including GO and TiO2, TiO2–GO could more significantly improve the resistance of corrosion with the help of IPTMS. Furthermore, the anti-corrosion mechanism of TiO2–GO in epoxy was tentatively proposed and discussed. Considering the high reactivity of IPTMS, our method is much easier to realize, and it helps to improve the reaction efficiency. In addition, the GO, nano-TiO2, and TiO2–GO nanocomposites were added into epoxy, respectively, with a low weight loading. Then, the corrosion resistance behavior and dispersion performance of all the films were tested and compared. GO was synthesized by the Hummers method, and the preparation process of TiO2–GO nanocomposites went through two separate steps. The first step was preparing functionalized GO (F–GO) with the help of 3-Isocyanatopropyltrimethoxysilane. Another step was synthesizing TiO2–GO nanocomposites that decorating F–GO with nano-TiO2.[1]

The specific procedures were as follows: Firstly, 0.1 g GO was added in 50 mL DMF and sonicated for 20 min to be a homogeneous state. Then 1 g 3-Isocyanatopropyltrimethoxysilane was dropped in the solution under stirring at 105 °C for 2 h. Subsequently, the suspension was centrifuged and washed with anhydrous ethanol three times to remove the residual 3-Isocyanatopropyltrimethoxysilane and DMF to obtain F–GO. Next, the F–GO was dispersed in 25 mL ethanol and 0.03 g nano-TiO2 was dissolved in 25 mL DI both by ultrasound for 20 min. Subsequently, the nano-TiO2 was slowly dropped in the F–GO ethanol solution under rapid stirring at 60 °C for another 2 h. After that, the mixture was centrifuged and washed with DI and anhydrous ethanol three times, respectively. Lastly, the resultant product was dried at 55 °C for 24 h in the oven. Through the characterization results, it can be obtained that with the help of 3-Isocyanatopropyltrimethoxysilane nano-TiO2 successfully combined with GO through chemical bonds, and it indeed exhibits the good dispersity in the solvent system. In the meantime, the TiO2–GO/EP shows the outstanding anti-corrosion property from the EIS test. The results confirm that according to our modification methods, the combination of GO and nano-TiO2 could achieve the effect that one plus one is greater than two. Furthermore, these methods could be not only applied in this field, but also the other relevant area.

3-Isocyanatopropyltrimethoxysilane Used in Solid Phase Synthesis

Scientists investigate the replacement of amino silanes for the immobilisation of thiol-presenting templates—a common strategy for the imprinting of peptides and proteins. Herein we attempted to replace the amino silane and SIA linker with an iodo silane, 3-Isocyanatopropyltrimethoxysilane (IPTMS). In order to compare the performance of these two approaches, peptide-functionalised glass beads were prepared using both AHAMTES and IPTMS-based protocols. The amount of MIP nanoparticles collected following polymerisation, elution and dialysis was found to be 56 μg MIP/g glass beads using AHAMTES, and 72 μg MIP/g glass beads using 3-Isocyanatopropyltrimethoxysilane. Both MIPs prepared using AHAMTES and IPTMS showed excellent binding affinity (Kd of approximately 2 nM) for their specific peptide and significantly lower affinity (Kd of approximately 700 nM) for the scrambled control peptide.[2]

The dissociation constant for the scrambled control peptide was marginally lower for MIPs prepared using AHAMTES as a solid phase as compared to those made using 3-Isocyanatopropyltrimethoxysilane. This may possibly be attributed to the slightly higher level of silane contamination increasing the level of non-specific binding between the MIPs and the gold SPR chip. An additional advantage of IPTMS over amino silanes is the lack of residual amines on the surface of the glass beads following MIP formation. Post-synthetic labelling of MIPs is often performed using amine-reactive probes, such as NHS-ester-DyLight and AlexaFluor. Finally, alkyl halides, such as 3-Isocyanatopropyltrimethoxysilane are able to react with other nucleophilic groups beyond thiols (notably amines and aromatic alcohols, given basic enough conditions). As a result, the iodo silane-based methodology described herein can be used for the immobilisation of a wide variety of template molecules even in the absence of cysteine groups. An iodo silane (IPTMS) is presented as an alternative for peptide immobilisation, and was compared to an amino silane (AHAMTES) for the solid phase synthesis of MIP nanoparticles specific for an epitope of epidermal growth factor receptor (EGFR).

3-Isocyanatopropyltrimethoxysilane based membrane for gas separation

ZIF-8-IPTMS was synthesized using ZIF-8 crystals and 3-Isocyanatopropyltrimethoxysilane silane coupling agents based on the procedures reported in our previous work. In a typical preparation process, ZIF-8 (0.1 g), 3-Isocyanatopropyltrimethoxysilane (1 g), and DI water (100 g) were first incorporated into a round-bottom flask. After which, the mixture was heated at 110 °C for 1 h in an oil bath with a reflux condenser. Subsequently, the reaction system was subjected to centrifugation to collect the white product. Then, DI water was used to repeatedly wash the product. Lastly, the washed product was dried at 100 °C under vacuum conditions for 5 h, and it was later ground into a powder, which was denoted as ZIF-8-IPTMS. The as-prepared ZIF-8-IPTMS was later modified with 3N-APS amine compounds with various volume concentrations. Inspired by a previous report, the volume concentrations of the 3N-APS amine compounds were fixed as 10 vol%, 15 vol%, and 20 vol%.[3]

The porous ZIF-8-IPTMS-3N-APS was successfully synthesized in this work, and it was then used in CO2 adsorption separation and the subsequent preparation of the ZIF-8 membrane for CO2 separation. Considerable CO2 adsorption separation performances were achieved using the as-prepared ZIF-8-IPTMS-3N-APS owing to their high CO2 and negligible N2 and CH4 adsorption capacities. However, to achieve the continual operation of CO2 adsorption separation, these adsorbents have to regenerate which involves energy consumption.

References

[1]Li, Weihang et al. “Using 3-Isocyanatopropyltrimethoxysilane to Decorate Graphene Oxide with Nano-Titanium Dioxide for Enhancing the Anti-Corrosion Properties of Epoxy Coating.” Polymers vol. 12,4 837. 6 Apr. 2020, doi:10.3390/polym12040837

[2]Piletsky SS, Garcia Cruz A, Piletska E, Piletsky SA, Aboagye EO, Spivey AC. Iodo Silanes as Superior Substrates for the Solid Phase Synthesis of Molecularly Imprinted Polymer Nanoparticles. Polymers (Basel). 2022 Apr 14;14(8):1595. doi: 10.3390/polym14081595. PMID: 35458345; PMCID: PMC9026888.

[3]Qin Y, Xu L, Liu L, Deng X, Gao Y, Ding Z. Ultrathin porous amine-based solid adsorbent incorporated zeolitic imidazolate framework-8 membrane for gas separation. RSC Adv. 2021 Aug 27;11(46):28863-28875. doi: 10.1039/d1ra04801e. PMID: 35478573; PMCID: PMC9038122.