METHYL 3-FLUOROBENZOATE synthesis
- Product Name:METHYL 3-FLUOROBENZOATE
- CAS Number:455-68-5
- Molecular formula:C8H7FO2
- Molecular Weight:154.14
455-38-9
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$11.92/25g
455-68-5
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$14.00/5g
Yield: 75%
Reaction Conditions:
with hydrogenchloride in methanol;hexane
Steps:
2.A Methyl 3-Fluorobenzoate
EXAMPLE 2A Methyl 3-Fluorobenzoate To a solution of anhydrous hydrochloric acid (10.5 g) in anhydrous methanol (100 ml) is added m-fluorobenzoic acid (13.3 g.; 0.095 mole). The reaction mixture is stirred at room temperature overnight. The solvent and anhydrous hydrochloric acid are then removed under vacuum and the residue slurried with hexane (100 ml). The hexane insoluble layer is decanted and the hexane solution water washed (2*100 ml) before drying with anhydrous magnesium sulfate. The hexane filtrate is then concentrated under vacuum to afford 11.0 g (75% yield) of methyl 3-fluorobenzoate as a yellow liquid. Elemental anal. calcd. for C8 H7 FO2: C, 62.35; H, 4.57; F, 12.33. Found: C, 62.52; H, 4.70; F, 11.89.
References:
Rohm and Haas Company US4259510, 1981, A
67-56-1
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455-38-9
389 suppliers
$11.92/25g
455-68-5
142 suppliers
$14.00/5g
1711-07-5
336 suppliers
$6.00/5g
455-68-5
142 suppliers
$14.00/5g
![potassium trifluoro[3-(methoxycarbonyl)phenyl]boranuide](/CAS/20180703/GIF/1242733-94-3.gif)
1242733-94-3
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93-58-3
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$13.50/100 mL
455-68-5
142 suppliers
$14.00/5g