1-(2-Fluoro-4-nitrophenyl)pyrrolidine synthesis
- Product Name:1-(2-Fluoro-4-nitrophenyl)pyrrolidine
- CAS Number:385380-74-5
- Molecular formula:C10H11FN2O2
- Molecular Weight:210.2
Yield:385380-74-5 76%
Reaction Conditions:
with triethylamine in ethyl acetate at 20;
Steps:
21.1 [00338] Step 1) 1 -(2-fluoro-4-nitrophenyl)pyrrolidine
To a solution of pyrrolidine (0.78 g, 11 mmol) in EtOAc (15 mL) and Et3N (1.52 g, 15 mmol) was added l,2-difluoro-4-nitrobenzene (1.59 g, 10 mmol) in an ice bath. The mixture was stirred at rt overnight and filtered. The filter cake was washed with water and dried to give the title compound as a yellow solid (1.60 g, 76%).
References:
WO2014/12360,2014,A1 Location in patent:Paragraph 00338
367-11-3
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385380-74-5
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$19.00/1g