1,6-DIBROMO-2-HYDROXYNAPHTHALENE-3-CARBOXYLIC ACID synthesis
- Product Name:1,6-DIBROMO-2-HYDROXYNAPHTHALENE-3-CARBOXYLIC ACID
- CAS Number:1779-10-8
- Molecular formula:C11H6Br2O3
- Molecular Weight:345.97
92-70-6
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Yield: 91%
Reaction Conditions:
with bromine;acetic acid at 120; for 3 h;
Steps:
1.1 step 1:
1L three-necked flask,3-hydroxy-2-naphthoic acid (50 g, 0.27 mol)And 600 mL of glacial acetic acid, stirred and dissolved.Bromine (34 mL, 0.67 mol) was treated with 100 mLGlacial acetic acid diluted, slowly dropping into the reaction solution,Keep the temperature 20-30 ° C.After completion of the dropwise addition, the temperature was raised to 120 ° C,Reflux 3h. Stop heating,Naturally cooled to room temperature,The reaction solution was poured into 3000 mL of ice water,Precipitation of a large number of yellow solid,Filter, filter cake with water,Oven drying,To give 84 g of intermediate 2 as a solid, 91% yield.
References:
The Chinese People's Liberation Army Military Academy Of Medical Sciences Poison Pharmaceutical Institute;Zhong Wu;Li Song;Qiao Changjiang;Zhu Dianxi CN106866433, 2017, A Location in patent:Paragraph 0075; 0076; 0077
2208-15-3
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1779-10-8
112 suppliers
$14.00/5g
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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1779-10-8
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64-19-7
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1000210-73-0
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1779-10-8
112 suppliers
$14.00/5g
1000210-73-0
0 suppliers
inquiry
64-19-7
1581 suppliers
$10.00/25ML
92-70-6
436 suppliers
$10.00/10g
1779-10-8
112 suppliers
$14.00/5g