ChemicalBook CAS DataBase List 1-Boc-3-pyrrolidinecarbaldehyde

1-Boc-3-pyrrolidinecarbaldehyde synthesis

8synthesis methods

Product Name:1-Boc-3-pyrrolidinecarbaldehyde
CAS Number:59379-02-1
Molecular formula:C10H17NO3
Molecular Weight:199.25

114214-69-6

59379-02-1

General procedure for the synthesis of 1-Boc-3-pyrrolidinecarboxaldehyde from 1-Boc-3-hydroxymethylpyrrolidine: 1 kg of N-Boc-pyrrolidine-3-methanol was dissolved in 5 liters of dimethylsulfoxide (DMSO), and 2.14 kg of manganese dioxide was slowly added at room temperature. The reaction mixture was stirred at room temperature for about 24 hours to ensure complete reaction. Upon completion of the reaction, insoluble solids were removed by filtration and the filtrate was concentrated by rotary evaporator to remove solvent. Ultimately, N-Boc-pyrrolidine-3-carbaldehyde (920 g) was purified by reduced pressure distillation in 93% yield.

114214-69-6
225 suppliers
$6.00/250mg

59379-02-1
196 suppliers
$12.00/250mg

Yield: 93%

Reaction Conditions:

with manganese(IV) oxide in dimethyl sulfoxide at 20; for 24 h;Solvent;Reagent/catalyst;

Steps:

3.4 Example 3:
1 kg of N-Boc-pyrrolidine-3-methanol was dissolved in 5 liters of DMSO,Room temperature by adding manganese dioxide 2.14kg,Room temperature reaction for about 24 hours,Reaction is completed,filter,Spin dry solvent,N-Boc-pyrrolidine-3-carbaldehyde (920 g) was distilled off under reduced pressure,Yield 93%.

References:

Wuhan Hengda of Biomedical Co., Ltd.;Zhou, Yebing;Lu, Dongan;Liu, Jie;Zhang, Shengbo CN106588738, 2017, A Location in patent:Paragraph 0036; 0041; 0042; 0046; 0047; 0048

569667-93-2 Synthesis