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ChemicalBook CAS DataBase List (R)-methyl 2-chloro-6-(3-methylmorpholino)pyrimidine-4-carboxylate
1233339-69-9

(R)-methyl 2-chloro-6-(3-methylmorpholino)pyrimidine-4-carboxylate synthesis

3synthesis methods
953780-78-4 Synthesis
(R)-3-Methylmorpholine hydrochloride

953780-78-4
128 suppliers
$6.00/100mg

6299-85-0 Synthesis
Methyl 2,4-dichloropyrimidine-6-carboxylate

6299-85-0
185 suppliers
$10.00/1g

(R)-methyl 2-chloro-6-(3-methylmorpholino)pyrimidine-4-carboxylate

1233339-69-9
8 suppliers
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Yield:1233339-69-9 97.9%

Reaction Conditions:

with N-ethyl-N,N-diisopropylamine in water;dimethyl sulfoxide at 0 - 5; for 5 h;Industrial scale;

References:

Goundry, William R. F.;Dai, Kuangchu;Gonzalez, Miguel;Legg, Daniel;O'Kearney-Mcmullan, Anne;Morrison, James;Stark, Andrew;Siedlecki, Paul;Tomlin, Paula;Yang, Jianbo [Organic Process Research and Development,2019,vol. 23,# 7,p. 1333 - 1342]