4-CHLORO-5-METHOXY-2-METHYL-2,3-DIHYDROPYRIDAZIN-3-ONE synthesis
- Product Name:4-CHLORO-5-METHOXY-2-METHYL-2,3-DIHYDROPYRIDAZIN-3-ONE
- CAS Number:14628-57-0
- Molecular formula:C6H7ClN2O2
- Molecular Weight:174.59
933-76-6
134 suppliers
$7.00/250mg
124-41-4
726 suppliers
$12.00/25g
14628-57-0
31 suppliers
$45.00/10mg
Yield:14628-57-0 432mg
Reaction Conditions:
in methanol at 0 - 20; for 3 h;
Steps:
5.3 Synthesis of 4-chloro-5-methoxy-2-methyl-pyridazin-3-one
4,5-dichloro-2-methyl-3 (2H)-pyridazinone (500 mg, 2.70 mmol) was dissolved in methanol, 0 ° C. at 28% sodium methoxide - methanol solution (587 μL, 3.35 mmol) was added and the mixture was stirred at room temperature for 3 hours. To this suspension resulting residue was concentrated under reduced pressure was diluted with ethyl acetate, and washed with water. The organic phase was dried over anhydrous sodium sulfate to give the title compound (432 mg) by vacuum concentration.
References:
JP2016/37467,2016,A Location in patent:Paragraph 0063
67-56-1
782 suppliers
$9.00/25ml
933-76-6
134 suppliers
$7.00/250mg
14628-57-0
31 suppliers
$45.00/10mg
63910-43-0
111 suppliers
$38.00/1g
74-88-4
356 suppliers
$15.00/10g
14628-57-0
31 suppliers
$45.00/10mg
933-76-6
134 suppliers
$7.00/250mg
14628-57-0
31 suppliers
$45.00/10mg
25236-64-0
113 suppliers
$11.19/5G
63910-43-0
111 suppliers
$38.00/1g
14628-57-0
31 suppliers
$45.00/10mg