ALPHA-AMINOISOBUTYRIC ACID METHYL ESTER HYDROCHLORIDE synthesis
- Product Name:ALPHA-AMINOISOBUTYRIC ACID METHYL ESTER HYDROCHLORIDE
- CAS Number:15028-41-8
- Molecular formula:C5H12ClNO2
- Molecular Weight:153.61
67-56-1
62-57-7
15028-41-8
1. 2-Amino-2-methylpropionic acid (10 g, 96.9 mmol) and methanol (330 ml) were added to a reaction vial. 2. The reaction vial was placed in an ice bath and thionyl chloride (17.68 ml, 242.25 mmol) was slowly added dropwise. 3. After the dropwise addition was completed, the ice bath was removed and the reaction mixture was stirred at room temperature for 3 hours. 4. After completion of the reaction, the solvent was removed by vacuum distillation. 5. The residue was dried in an oven at 60 °C to give methyl 2-amino-2-methylpropionate hydrochloride as a white solid (14.59 g, 94.9 mmol, 98% yield). 6. The product was analyzed by 1H NMR. 6. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.75 (br, 3H), 3.75 (s, 3H), 1.45 (s, 6H).
62-57-7
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15028-41-8
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Yield:-
Reaction Conditions:
with thionyl chloride in methanol;diethyl ether
Steps:
3.H 3-((2R)-2-((benzyloxy)amino)-3-(4-bromophenoxy)propyl)-5,5-dimethyl-2,4-imidazolidinedione
EXAMPLE 3H 3-((2R)-2-((benzyloxy)amino)-3-(4-bromophenoxy)propyl)-5,5-dimethyl-2,4-imidazolidinedione A solution of 2-aminoisobutyric acid (51.7 g) in methanol (500 mL) at 0° C. was treated with thionyl chloride (80.4 g) over 35 minutes, stirred for 30 minutes, warmed to room temperature, heated to 50° C. for 3 hours, cooled to room temperature, and concentrated. The concentrate was dissolved in methanol (200 mL), concentrated, dissolved in warm methanol (50 mL), treated with diethyl ether (300 mL), and filtered. The resulting solid was dried under vacuum (100 mm Hg) at 50° C. with a nitrogen bleed to provide 59.6 g of methyl 2-amino-2-methylpropanoate hydrochloride.
References:
Bailey, Anne E.;Hill, David R.;Hsiao, Chi-Nung W.;Kurukulasuriya, Ravi;Wittenberger, Steve;McDermott, Todd;McLaughlin, Maureen A. US2002/19539, 2002, A1
67-56-1
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62-57-7
450 suppliers
$10.64/25G
15028-41-8
220 suppliers
$9.00/10g
84758-55-4
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15028-41-8
220 suppliers
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62-57-7
450 suppliers
$10.64/25G
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15028-41-8
220 suppliers
$9.00/10g