(1S.2R)-1-Benzyloxy-2-(benzyloxymethyl)-3-cyclopentene synthesis
- Product Name:(1S.2R)-1-Benzyloxy-2-(benzyloxymethyl)-3-cyclopentene
- CAS Number:191480-69-0
- Molecular formula:C20H22O2
- Molecular Weight:294.39
100-39-0
439 suppliers
$10.00/10g
110567-21-0
184 suppliers
$7.00/1g
191480-69-0
5 suppliers
inquiry
Yield:191480-69-0 97.4%
Reaction Conditions:
Stage #1: (1S,2R)-2-(benzyloxymethyl)-1-hydroxy-3-cyclopentenewith sodium t-butanolate in tetrahydrofuran at 20; for 0.416667 h;Inert atmosphere;
Stage #2: benzyl bromide in tetrahydrofuran at -5; for 0.583333 h;Inert atmosphere;Temperature;
Steps:
1; 3; 5 Example 5: Preparation method of compound NT01B
5.0 g of compound NT01A was dissolved in 60 mL of anhydrous THF.Under the protection of nitrogen,Add 3.46g sodium tert-butoxide,Stir at room temperature for about 25 minutes.Then, 6.10g of benzyl bromide was added dropwise to the reaction solution at -5°C,After continuing the reaction for 35 minutes,Warm up to room temperature,To the end of the reaction.Spin the reaction solution to dryness,The residue was purified by silica gel column chromatography (eluent: petroleum ether ethyl acetate = 5/1),7.03g product is obtained,The yield was 97.4%.
References:
CN113024490,2021,A Location in patent:Paragraph 0031-0033; 0037-0039; 0043-0045
3587-60-8
330 suppliers
$10.00/1g
191480-69-0
5 suppliers
inquiry
![Benzene, [(2,4-cyclopentadien-1-ylmethoxy)methyl]-](/CAS/20200119/GIF/39939-07-6.gif)
39939-07-6
2 suppliers
inquiry
191480-69-0
5 suppliers
inquiry
542-92-7
95 suppliers
inquiry
191480-69-0
5 suppliers
inquiry