1H-BENZOTRIAZOLE-1-METHANOL synthesis
- Product Name:1H-BENZOTRIAZOLE-1-METHANOL
- CAS Number:28539-02-8
- Molecular formula:C7H7N3O
- Molecular Weight:149.15
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Example 30 Synthesis of 1H-benzotriazole-1-methanol: 10 g (83.94 mmol) of 1H-benzotriazole was dissolved in 6.81 mL (83.94 mmol) of 37% formaldehyde aqueous solution. The temperature of the mixture was adjusted to 25°C under stirring. After 5 minutes of reaction, the mixture was cured. Subsequently, the reaction mixture was cooled to room temperature, filtered and washed with ether. The resulting solid was ground in cold tetrahydrofuran and filtered again (Int.94). Product yield: 94%, melting point: 148-150°C (determined by recrystallization from tetrahydrofuran and ether).
Yield:28539-02-8 94%
Reaction Conditions:
in water at 25; for 0.0833333 h;
Steps:
30
Example 30 1-Hydroxymethyl-1H-benzotriazole [0464] Dissolve 10 g (83.94 mmol) of 1H-benzotriazole in 6.81 mL (83.94 mmol) of a 37% aqueous solution of formaldehyde. Stir and bring the mixture to a temperature of 25° C. After 5 minutes, the reaction mixture solidifies. Cool the solution to ambient temperature. Filter and wash with diethyl ether. Triturate the residue in the cold in tetrahydrofuran and filter (Int. 94). [0465] Yield: 94% [0466] Melting point: 148-150° C. (tetrahydrofuran and diethyl ether)
References:
Le Borgne, Marc;Na, Young Min;Pagniez, Fabrice;Le Baut, Guillaume;Le Pape, Patrice;Abdala, Hiam US2004/67998, 2004, A1 Location in patent:Page/Page column 24
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