2,2-Difluoropropionic acid synthesis
- Product Name:2,2-Difluoropropionic acid
- CAS Number:373-96-6
- Molecular formula:C3H4F2O2
- Molecular Weight:110.06
28781-85-3
373-96-6
The general procedure for synthesizing 2,2-difluoropropionic acid from ethyl 2,2-difluoropropionate was as follows: referring to Example G38, ethyl 2,2-difluoropropionate (1.2 g, 8.8 mmol) was dissolved in ethanol (26 mL), followed by the slow addition of 2N aqueous sodium hydroxide solution (26 mL). The reaction mixture was stirred at 0 °C, then gradually warmed to room temperature and continued stirring for 14 hours. Upon completion of the reaction, the reaction mixture was acidified to pH < 7 with 2N hydrochloric acid and then extracted with ether. The organic phases were combined, dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure to give 2,2-difluoropropionic acid (0.90 g, 92% yield). The product was an oil with the following 1H-NMR (CDCl3) data: δ 1.85 (3H, t, J = 19.0 Hz), 6.21 (1H, br s).
28781-85-3
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373-96-6
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Yield:373-96-6 92%
Reaction Conditions:
with aqueous sodium hydroxide in ethanol;
Steps:
R.G.38 2,2-difluoropropionic acid
Reference Example G 38 2,2-difluoropropionic acid A solution of ethyl 2,2-difluoropropionate (1.2 g, 8.8 mmol) in ethanol (26 mL) was added to 2N aqueous sodium hydroxide (26 mL) and the resulting mixture was stirred at room temperature for 14 hours. The reaction mixture was acidified with 2N hydrochloric acid and extracted with ether. The extracts were dried, and concentrated under reduced pressure to give the title compound (0.90 g, yield 92%). oil 1H-NMR(CDCl3) d: 1.85 (3H, t, J= 19.0Hz), 6.21 (1H, br s).
References:
EP1402900,2004,A1
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