2-(2-OXO-PYRROLIDIN-1-YL)-BUTYRIC ACID ETHYL ESTER synthesis
- Product Name:2-(2-OXO-PYRROLIDIN-1-YL)-BUTYRIC ACID ETHYL ESTER
- CAS Number:86815-10-3
- Molecular formula:C10H17NO3
- Molecular Weight:199.25
64-17-5
757 suppliers
$10.00/50g
67118-31-4
123 suppliers
$94.25/1g
86815-10-3
13 suppliers
$175.00/500mg
Yield:86815-10-3 90.1%
Reaction Conditions:
with sulfuric acid at 78 - 80; for 2 h;
Steps:
3 Preparation of α-ethyl-2-oxo-1-pyrrolidine acetate (II)
Add α-ethyl-2-oxo-1-pyrrolidine acetic acid (50g, 0.29mol) to the reaction flaskand ethanol (150g), dropwise added concentrated sulfuric acid (5g), heated to 7880 and refluxed for 2 hours under stirring, added water (100g), controlled the temperature in the range of 4060,Add 15% Na2CO3 solution dropwise until the pH of the reaction system is 7.0-7.5,The remaining ethanol was evaporated under reduced pressure at a temperature of 40-50 °C, and the residual liquid was extracted with dichloromethane (100 g) three times.Combine the organic phases, distill under reduced pressure until no liquid flows out,get Alpha-ethyl-2-oxo-1-pyrrolidine ethyl acetate,Yield 52.4 g, yield 90.1%, HPLC purity 99.3%.
References:
CN113861090,2021,A Location in patent:Paragraph 0039-0041
616-45-5
396 suppliers
$14.00/25g
533-68-6
384 suppliers
$5.00/10g
86815-10-3
13 suppliers
$175.00/500mg
14468-90-7
87 suppliers
$49.20/10g
533-68-6
384 suppliers
$5.00/10g
616-45-5
396 suppliers
$14.00/25g
10544-63-5
59 suppliers
inquiry
2857-97-8
444 suppliers
$7.00/25g
86815-10-3
13 suppliers
$175.00/500mg