2,3-Difluoroaniline synthesis
- Product Name:2,3-Difluoroaniline
- CAS Number:4519-40-8
- Molecular formula:C6H5F2N
- Molecular Weight:129.11
1481-57-8
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4519-40-8
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Yield:4519-40-8 93%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen;triethylamine in methanol at 50; for 2.5 h;Temperature;
Steps:
16 Example 16 (Production of 2,3-difluoroaniline)
First, 0.638 g (2.01 mmol) of 1,2-dibromo-4,5-difluoro-3-nitrobenzene was dissolved in 4 mL of methanol, and then 48.4 mg of 10% Pd/C (50% wet) and 6.2 mg (0.06 mmol) of triethylamine were added. The atmosphere inside the reaction vessel was substituted with hydrogen, and the reaction mixture was reacted at 50°C for 2 hours under slight hydrogen pressurization. Analysis of the resulting reaction product by HPLC revealed 2.2 area% of 2,3-dibromo-5,6-difluoroaniline as a residual intermediate. Reaction was continued under the same conditions for a further 0.5 hours. The catalyst was then removed by filtration. The resulting liquid was subjected to quantitative analysis by HPLC. The yield of 2,3-difluoroaniline was 93%. The intermediate 2,3-dibromo-5,6-difluoroaniline had been eliminated.
References:
EP2940002,2015,A1 Location in patent:Paragraph 0075
771-69-7
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4519-40-8
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87-61-6
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5509-65-9
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4519-40-8
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4519-40-8
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