2-(5-FLUOROPYRIDIN-2-YL)ACETIC ACID synthesis
- Product Name:2-(5-FLUOROPYRIDIN-2-YL)ACETIC ACID
- CAS Number:1000515-83-2
- Molecular formula:C7H6FNO2
- Molecular Weight:155.13
1006686-15-2
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1000515-83-2
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Yield:1000515-83-2 44%
Reaction Conditions:
with water;lithium hydroxide in tetrahydrofuran at 60; for 24 h;
Steps:
1.K Step K: 2- (5-fluoropyridin-2-yl) acetic acid
At room temperature, add 2- (5-fluoropyridin-2-yl) ethyl acetate (5.5g, 0.03mol), tetrahydrofuran (50mL), water (10mL), lithium hydroxide (1.44g, 0.06) mol), react at 60 ° C for 24 hours, TLC detects the reaction of the raw materials is completed, the reaction solution is concentrated to one-third of the volume of the original reaction solution, ethyl acetate is added for extraction, and the layers are separated to obtain an aqueous phase. Around 3, extract with ethyl acetate again, combine the organic phases, dry over anhydrous sodium sulfate, filter, and concentrate under reduced pressure to obtain the product 2- (5-fluoropyridin-2-yl) acetic acid (2.04g, 44% yield) .
References:
CN110964008,2020,A Location in patent:Paragraph 0185; 0220-0222
1186309-52-3
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1000515-83-2
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41404-58-4
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1000515-83-2
44 suppliers
$45.00/10mg