2,6-Dichloro-3-nitropyridine synthesis
- Product Name:2,6-Dichloro-3-nitropyridine
- CAS Number:16013-85-7
- Molecular formula:C5H2Cl2N2O2
- Molecular Weight:192.99
16013-84-6
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16013-85-7
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Yield:16013-85-7 92.9%
Reaction Conditions:
with bis(trichloromethyl) carbonate in N,N-dimethyl-formamide at 80 - 85; for 6 h;Solvent;Temperature;Reagent/catalyst;
Steps:
5-7 Example 7: Preparation of 2,6-dichloro-3-nitropyridine
To a 250 ml four-necked flask equipped with a thermometer, mechanical stirring, and reflux condenser, 70 g of N,N-dimethylformamide was added.31.2 g (0.2 mol) of 2,6-dihydroxy-3-nitropyridine,38.6 g (0.13 mol) of triphosgene, stirring reaction at 80-85 ° C for 6 hours,Cool to 20-25 ° C,Slowly pour the residue into 200 grams of ice water.Extract three times with chloroform, 50 grams each time.The organic phases were combined and washed with 30 g of saturated brine.Then dried with 5 g of anhydrous sodium sulfate.The solvent was removed by rotary evaporation to give 35.5 g, m.The yield is 92.9%.The liquid phase purity was 99.3%
References:
CN110218177,2019,A Location in patent:Paragraph 0040-0045
2402-78-0
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148493-34-9
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16013-85-7
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120-43-4
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16013-85-7
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