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ChemicalBook CAS DataBase List 2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile
82671-02-1

2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile synthesis

1synthesis methods
2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile can be used as organic intermediate and pharmaceutical intermediate, mainly used in laboratory research. It can be synthesized by the reaction of 5-fluoro-6-hydroxy-2-oxo-1H-pyridine-3-carboxamide with phosphorus pentachloride at 130℃.
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Yield:82671-02-1 77%

Reaction Conditions:

with phosphorus pentachloride at 130; for 2.5 h;

References:

Miyamoto;Egawa;Matsumoto [Chemical and Pharmaceutical Bulletin,1987,vol. 35,# 6,p. 2280 - 2285]

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