天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 2,6-DIIODOPYRAZINE
58138-79-7

2,6-DIIODOPYRAZINE synthesis

1synthesis methods
2,6-Dichloropyrazine

4774-14-5

2,6-DIIODOPYRAZINE

58138-79-7

General procedure for the synthesis of 2,6-diiodopyrazine from 2,6-dichloropyrazine: 2,6-dichloropyrazine (2.5 g, 16.8 mmol, 1.0 eq.), p-toluenesulfonic acid (6.4 g, 33.6 mmol, 2.0 eq.), sodium iodide (20.0 g, 133.3 mmol, 8.0 eq.), 15-crown-5 (2.0 mL), and cyclobutanesulfone (40 mL) were mixed in a sealed tube and the reaction was heated at 150 °C for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and water (100 mL) was added to the reaction mixture. The reaction mixture was neutralized with saturated sodium bicarbonate solution and subsequently washed with saturated sodium thiosulfate solution. The mixture was extracted with ether (5 x 100 mL), the ether extracts were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. Water (10 mL) was added to the concentrate to precipitate 2,6-diiodopyrazine, the solid was collected by filtration, washed sequentially with water and pentane, and freeze-dried to give a light yellow powdery product (2.1 g, 38% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.74 (s, 2H); mass spectrum (M+H)+ = 332, retention time (Rt) = 1.29 min.

-

Yield:58138-79-7 89%

Reaction Conditions:

with hydrogen iodide;sodium iodide in water at 100; for 1 h;Inert atmosphere;Schlenk technique;

References:

Jackson, Jeffrey J.;Kobayashi, Hiroyuki;Steffens, Sophia D.;Zakarian, Armen [Angewandte Chemie - International Edition,2015,vol. 54,# 34,p. 9971 - 9975][Angew. Chem.,2015,vol. 127,p. 10109 - 10113,5] Location in patent:supporting information

2,6-DIIODOPYRAZINE Related Search: