(2,6-DIMETHYLPYRIDIN-4-YL)METHANOL synthesis
- Product Name:(2,6-DIMETHYLPYRIDIN-4-YL)METHANOL
- CAS Number:18088-01-2
- Molecular formula:C8H11NO
- Molecular Weight:137.18
67-56-1
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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18088-01-2
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$77.50/250 mg
Yield: 40%
Reaction Conditions:
with ammonium persulfate in water for 1 h;Reflux;
Steps:
1.1
Lutidine-N-methoxide (2 g, 8 mmol) was dissolved in 25 mL of methanol and heated to reflux. To this mixture a solution of ammonium persulfate (456 mg, 4 mmol) in 3 mL of water was added. The reflux was continued for 1 hour. The crude was cooled to roomtemperature, and pH was adjusted to 7 using 10% NaOH. The crude was filtered and evaporated to dryness. The final compound was purified on silica gel, to obtain 440 mg of the desired intermediate (iic) as a white solid. Yield: 40%. ‘H NMR (400 MHz, Chloroform-d) ?:6.88 (s, 2H), 4.58 (s, 2H), 2.41 (s, 6H). ‘3C NMR (101 MHz, Chloroform-d) ?: 157.78,150.71, 117.80, 63.43, 24.27.
References:
UNIVERSITE DE GENEVE;RANDO, Gianpaolo;WINSSINGER, Nicolas;LINDBERG, Eric;ANZOLA, Marcello WO2018/69470, 2018, A1 Location in patent:Page/Page column 26; 31
1073-23-0
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18088-01-2
75 suppliers
$77.50/250 mg
108-48-5
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$6.09/190ul
67-56-1
782 suppliers
$7.29/5ml-f
18088-01-2
75 suppliers
$77.50/250 mg
108-48-5
491 suppliers
$6.09/190ul
18088-01-2
75 suppliers
$77.50/250 mg