2-amino-2'-chlorobenzophenone synthesis
- Product Name:2-amino-2'-chlorobenzophenone
- CAS Number:2894-45-3
- Molecular formula:C13H10ClNO
- Molecular Weight:231.68
![Carbamic acid, N-[2-(2-chlorobenzoyl)phenyl]-, 1,1-dimethylethyl ester](/CAS/20210305/GIF/622372-96-7.gif)
622372-96-7
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2894-45-3
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Yield: 83%
Reaction Conditions:
with hydrogenchloride in acetic acid at 20; for 3 h;
Steps:
44
Dissolve [2- (2-chloro-benzoyl)-phenyl]-carbamic acid tert-butyl ester (850 mg, 2.6 mmol) in a saturated HC1 in AcOH solution (10 mL,-3N in HC1), stir at room temperature for 3 hours. Concentrate, add CHC13 and concentrate (3x) to remove remaining AcOH. Dissolve the residue in 20% i-PrOH/CHC13, wash with saturated NaHCO3 solution (2x) and brine. Dry the combined organic layers over MgS04 and concentrate to afford the title compound (495 mg, 83%): MS (IS) 232 (M+1).
References:
Location in patent:Page/Page column 44
2894-44-2
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2894-45-3
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1444-72-0
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2894-45-3
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