2-Amino-5-bromo-3-fluorophenol synthesis
- Product Name:2-Amino-5-bromo-3-fluorophenol
- CAS Number:186309-73-9
- Molecular formula:C6H5BrFNO
- Molecular Weight:206.01
1618663-94-7
0 suppliers
inquiry
186309-73-9
30 suppliers
$282.75/1g
Yield:186309-73-9 92%
Reaction Conditions:
with boron tribromide in dichloromethane at 0 - 20; for 2 h;
Steps:
33 2-Amino-5-bromo-3-fluorophenol
To a suspension of 4-bromo-2-fluoro-6-methoxyaniline hydrobromide (1 equiv) in DCM (0.3 M) was added boron tribromide (2 equiv) in DCM at 0° C. The reaction mixture was stirred at room temperature for 2 h. After quenching, the reaction mixture was diluted with DCM then purified by silica gel chromatography (0 to 100% ethyl acetate in hexane) to give the title compound (92% yield). MS (ESI) m/z 205.9 [M+H]+.
References:
US2014/200206,2014,A1 Location in patent:Paragraph 0400
1261216-27-6
17 suppliers
$200.00/100mg
186309-73-9
30 suppliers
$282.75/1g
941608-28-2
7 suppliers
inquiry
186309-73-9
30 suppliers
$282.75/1g
446-61-7
129 suppliers
$10.00/100mg
186309-73-9
30 suppliers
$282.75/1g
53981-23-0
103 suppliers
$21.00/250mg
186309-73-9
30 suppliers
$282.75/1g