2-Amino-7-bromobenzothiazole synthesis
- Product Name:2-Amino-7-bromobenzothiazole
- CAS Number:20358-05-8
- Molecular formula:C7H5BrN2S
- Molecular Weight:229.1
21327-14-0
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20358-03-6
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20358-05-8
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Yield:-
Reaction Conditions:
with bromine in dichloromethane at 20;Overall yield = 82 %; Overall yield = 809 mg;
Steps:
118.1 [838] Step 1: a mixture of 5-bromobenzo[d]thiazol-2-amine and 7-bromobenzo[d]thiazol-2-amine
[838] Step 1: a mixture of 5-bromobenzo[d]thiazol-2-amine and 7-bromobenzo[d]thiazol-2-amine[839] To a stirred solution of 1-(3-bromophenyl)thiourea (1.00 g, 4.33 mmol) in dichloromethane (15 mL) was added dropwise a solution of bromine (345 mg, 4.33 mmol) in dichloromethane (15 mL). The reaction mixture was stirred at room temperature overnight. The resulting solid was filtered, washed with dichloromethane, and then dried under reduced pressure to give 809 mg of the titled compound as a yellow solid (Yield: 82%).
References:
YUHAN CORPORATION;HUR, Youn;KIM, Dong-Hyun;KIM, Eun-Kyung;PARK, Jin-Hwi;JOO, Jae-Eun;KANG, Ho-Woong;OH, Se-Woong;KIM, Dong-Kyun;AHN, Kyoung-Kyu WO2013/43001, 2013, A1 Location in patent:Paragraph 838; 839
21327-14-0
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20358-05-8
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15864-32-1
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20358-05-8
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20358-05-8
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20358-05-8
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