2-Bromo-4-fluoroaniline synthesis
- Product Name:2-Bromo-4-fluoroaniline
- CAS Number:1003-98-1
- Molecular formula:C6H5BrFN
- Molecular Weight:190.01
371-40-4
1003-98-1
The general procedure for the synthesis of 2-bromo-4-fluoroaniline from 4-fluoroaniline was as follows: 200 mL of distilled N,N-dimethylformamide (DMF) and 4-fluoroaniline (8.64 mL, 58.13 mmol) were added to a two-necked flask equipped with a stirring device. N-bromosuccinimide (11.4 g, 63.95 mmol) dissolved in DMF was added slowly and dropwise with stirring. After completion of the reaction, extraction was carried out using dichloromethane (CH2Cl2). The product was purified by column chromatography (eluent ratio of ethyl acetate: n-hexane = 1:4), and the target product 2-bromo-4-fluoroaniline was finally obtained in 95% yield.
371-40-4
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1003-98-1
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Yield:1003-98-1 95%
Reaction Conditions:
with N-Bromosuccinimide in N,N-dimethyl-formamide;
Steps:
3.1.1-5
Add 200 mL distilled DMF and 4-fluoroaniline (8.64 mL, 58.13 mmol) to a two neck flask. Slowly dropwise N-Bromosuccinimide (11.4 g, 63.95 mmol) dissolved in DMF. When the reaction is complete, extract with CH2Cl2. Purification by column separation (EA: Hx = 1: 4) (yield: 95%)
References:
KR2018/50795,2018,A Location in patent:Paragraph 0134; 0135; 0152-0154
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1003-98-1
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1009-22-9
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1003-98-1
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351-83-7
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1003-98-1
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