2-Bromo-5-iodopyridine synthesis
- Product Name:2-Bromo-5-iodopyridine
- CAS Number:73290-22-9
- Molecular formula:C5H3BrIN
- Molecular Weight:283.89
223463-14-7
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73290-22-9
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Yield:73290-22-9 79%
Reaction Conditions:
with perfluoroisopropyl iodide;copper;hydroquinone in N,N-dimethyl-formamide at 20; for 24 h;
Steps:
1 4.1. Typical procedure for the iodination of 1a-t by (CF3)2CFI
General procedure: (4-Nitrophenyl)boronic acid (0.067 g, 0.4 mmol), copper powder (0.0052 g, 0.08 mmol,), (CF3)2CFI (0.178 g, 0.6 mmol), and DMF (2 mL) were placed in a closed tube with a rubber stopper. The mixture was reacted at room temperature equipped with an air balloon for 24 h. The resulting suspension was poured into water and extracted with ethyl acetate. The organic layer was dried over anhydrous Na2SO4 and concentrated to dryness. The crude product was purified by flash column chromatography on silica gel using petroleum ether/ethyl acetate = 20: 1 (v/v) as eluent to give 0.086 g of 2j as a light yellow solid (0.35 mmol, 87%).
References:
Liu, Xi-Hai;Leng, Jing;Jia, Su-Jiao;Hao, Jian-Hong;Zhang, Fanglin;Qin, Hua-Li;Zhang, Cheng-Pan [Journal of Fluorine Chemistry,2016,vol. 189,p. 59 - 67]
20511-12-0
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73290-22-9
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624-28-2
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73290-22-9
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13534-97-9
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73290-22-9
345 suppliers
$6.00/1g
624-28-2
727 suppliers
$5.00/5g
73290-22-9
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$6.00/1g
223463-13-6
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