2-Methylbenzyl cyanide synthesis
- Product Name:2-Methylbenzyl cyanide
- CAS Number:22364-68-7
- Molecular formula:C9H9N
- Molecular Weight:131.17
773837-37-9
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Yield:-
Reaction Conditions:
with iron(III) chloride;N-benzyl-N,N,N-triethylammonium chloride;boric acid in water at 30; for 1 h;Reagent/catalyst;Temperature;
Steps:
1.2; 2.2; 3.2
The specific process of step (2) is to add 2352g of 25% sodium cyanide aqueous solution (in which sodium cyanide is 12mol) in a 3000 liter reaction flask, increase the temperature to 30°C, and add o-methylbenzyl chloride dropwise 1540g (11mol), add 9.24g of quaternary ammonium salt catalyst (tetramethylammonium chloride), 8.91g (0.055mol) of alkali binding agent (ferric chloride) and 6.71g (0.11mol) of boric acid, control the temperature to maintain 30 When the content of o-methylbenzyl chloride is less than 0.1%, the temperature-preservation reaction is finished. Fill the container with water, let it stand for 1h, separate layers, and obtain o-methylbenzeneacetonitrile through distillation.
References:
Ningxia Sike Da Biological Technology Co., Ltd.;Tian Yongfu;Qian Yunxiang;Zhang Kang;Liu Xiaozhou CN112125876, 2020, A Location in patent:Paragraph 0034; 0042-0043; 0046-0047; 0056-0057; 0060-0061
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