2-(PENTAFLUOROPHENOXY)ETHYL BROMIDE synthesis
- Product Name:2-(PENTAFLUOROPHENOXY)ETHYL BROMIDE
- CAS Number:6669-01-8
- Molecular formula:C8H4BrF5O
- Molecular Weight:291.01
2192-55-4
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Yield:6669-01-8 99%
Reaction Conditions:
with N-Bromosuccinimide;triphenylphosphine in acetonitrile at 125; for 0.194444 h;Microwave irradiation;
Steps:
25
In a lOmL glass tube were placed 2- (2, 3,4, 5,6-pentafluorophenoxy) ethanol (0. 250G, L. LMMOL), NBS (0.215g, 1. 2MMOL), triphenylphosphine (0.316g, 1. 2MMOL), 4mL of CH3CN and a magnetic stir bar. The vessel was sealed with a septum and placed into the microwave cavity. Microwave irradiation was used, and the reaction mixture was keep at 125°C for 700 seconds. After the mixture was allowed to cool to room temperature, the reaction vessel was opened and the contents were concentrated under vacuum. The crude residue was purified by flash chromatography (ethyl acetate/hexanes, 100% hexanes to 1: 4) to give 0.330g (99%) OF 2-BROMO-L- (2, 3,4, 5, 6-PENTAFLUOROPHENOXY) ethane as colorless oil. 'H NMR (300 MHz, CDC13) : 8 4.45 (2H, t), 3.62 (2H, t).
References:
WO2005/27856,2005,A2 Location in patent:Page/Page column 55
