2-(Trifluoromethoxy)nitrobenzene synthesis
- Product Name:2-(Trifluoromethoxy)nitrobenzene
- CAS Number:1644-88-8
- Molecular formula:C7H4F3NO3
- Molecular Weight:207.11
554-84-7
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1644-88-8
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$10.00/1g
Yield: 62%
Reaction Conditions:
antimonypentachloride in tetrachloromethane
Steps:
2 nitrophenyl trifluoromethyl ether
nitrophenyl trifluoromethyl ether Using the same reactor setup as in Example 1, the reactor is charged with 3-nitrophenol (13.9 g, 0.1 mol), anhydrous carbon tetrachloride (38 ml, 0.39 mol), anhydrous antimony trifluoride (53.6 g, 0.3 mol) and a catalytic amount of antimony pentachloride (1 ml, 7.7 mmol). The reactor is then sealed and heated at 150° C (internal) with vigorous stirring for 5.5 hours. Subsequently, the reactor is opened and the contents neutralized with saturated NaHC03 The product is separated by steam distillation, and a 62 percent yield of the product is obtained.
References:
The Dow Chemical Company US4950802, 1990, A
100-02-7
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7783-56-4
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1644-88-8
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175676-65-0
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1644-88-8
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1644-88-8
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