19-Nor-17-alpha-pregna-3,5-dien-20-yne-3,17-diol, diacetate synthesis
- Product Name:19-Nor-17-alpha-pregna-3,5-dien-20-yne-3,17-diol, diacetate
- CAS Number:2205-78-9
- Molecular formula:C24H30O4
- Molecular Weight:382.49
68-22-4
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$28.00/250mg
75-36-5
591 suppliers
$17.92/100G
2205-78-9
23 suppliers
$145.00/100mg
Yield:2205-78-9 110 kg
Reaction Conditions:
with pyridine;acetic anhydride at 20; for 6 h;Industrial scale;
Steps:
1.2.1 Acylation reaction
Step 1) 100kg norethindrone (II) obtained is added with 200kg acetic anhydride, 100kg pyridine, 120kg acetyl chloride is added dropwise at room temperature, and the reaction is stirred for 6 hours. TLC analysis of the raw material is complete, 1000kg water is added, centrifuged, dried to obtain acyl Compound (III) 110kg, mass yield 110%, detection HPLC ≥98%, single impurity ≤1.0%.
References:
CN110981930,2020,A Location in patent:Paragraph 0028-0029; 0032-0033
68-22-4
451 suppliers
$28.00/250mg
2205-78-9
23 suppliers
$145.00/100mg
111-87-5
785 suppliers
$6.00/100g
2205-78-9
23 suppliers
$145.00/100mg
1091-93-6
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inquiry
2205-78-9
23 suppliers
$145.00/100mg
17976-32-8
16 suppliers
$165.00/250mg
2205-78-9
23 suppliers
$145.00/100mg