3,4-Dimethoxybenzophenone synthesis
- Product Name:3,4-Dimethoxybenzophenone
- CAS Number:4038-14-6
- Molecular formula:C15H14O3
- Molecular Weight:242.27
in the presence of aluminium chloride in carbon disulfide (68%)
in the presence of zinc chloride.
Yield:4038-14-6 100%
Reaction Conditions:
with bismuth(lll) trifluoromethanesulfonate for 0.0833333 h;Ionic liquid;Microwave irradiation;Friedel-Crafts acylation;
Steps:
Typical procedure: Bi(OTf)3 (0.0328 g, 0.05 mmol), [BMI][PF6] (0.5 g), anisole (0.108 g, 1 mmol), and acetic anhydride (0.102 g, 1 mmol) were stirred at 80 °C for 30 min. After cooling, the reaction mixture was extracted by diethyl ether (2 × 40 mL). The ether layer was decanted, washed with water, aqueous NaHCO3, and brine, and dried over MgSO4. The solvent was then removed on a rotary evaporator. The residue was purified by flash chromatography (n-hexane/ethyl acetate = 9:1) to give 4-methoxyacetophenone (0.120 g, 80% yield).
References:
Tran, Phuong Hoang;Duus, Fritz;Le, Thach Ngoc [Tetrahedron Letters,2012,vol. 53,# 2,p. 222 - 224] Location in patent:experimental part
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