3-FLUORO-4-IODOPYRIDINE synthesis
- Product Name:3-FLUORO-4-IODOPYRIDINE
- CAS Number:22282-75-3
- Molecular formula:C5H3FIN
- Molecular Weight:222.99
372-47-4
380 suppliers
$5.00/1g
22282-75-3
130 suppliers
$9.00/1g
146141-04-0
94 suppliers
$36.00/250mg
Yield: 57% ， 37%
Reaction Conditions:
Stage #1:3-Fluoropyridine with 2,2,6,6-tetramethyl-piperidine;n-butyllithium;zinc dichloro(N,N,N′,N′-tetramethylethylenediamine) in tetrahydrofuran;hexane at 20; for 2 h;Inert atmosphere;
Stage #2: with iodine in tetrahydrofuran;hexane at 20;Inert atmosphere;regioselective reaction;Concentration;
References:
Hedidi, Madani;Bentabed-Ababsa, Ghenia;Derdour, A?cha;Halauko, Yury S.;Ivashkevich, Oleg A.;Matulis, Vadim E.;Chevallier, Floris;Roisnel, Thierry;Dorcet, Vincent;Mongin, Florence [Tetrahedron,2016,vol. 72,# 17,p. 2196 - 2205]
372-47-4
380 suppliers
$5.00/1g
22282-75-3
130 suppliers
$9.00/1g