4,6-DIFLUOROPYRIMIDINE synthesis
- Product Name:4,6-DIFLUOROPYRIMIDINE
- CAS Number:2802-62-2
- Molecular formula:C4H2F2N2
- Molecular Weight:116.07
1193-21-1
2802-62-2
a) Preparation of 4,6-difluoropyrimidine (STR13): 4,6-dichloropyrimidine (223.5 g, 1.5 mol), potassium fluoride (279.6 g, 4.8 mol) and tetrabutylammonium bromide (6.0 g, 0.0186 mol) were dissolved in cyclobutanesulfone (1 L). The reaction mixture was heated at 180-190 °C for 3.5 h followed by distillation to afford the target product 4,6-difluoropyrimidine as a white liquid (115 g, 66% yield).
1193-21-1
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$13.00/5g
2802-62-2
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$23.00/1g
Yield: 66%
Reaction Conditions:
with potassium fluoride;tetrabutylammomium bromide in sulfolane
Steps:
2.a a)
a) Preparation of 4,6-Difluoropyrimidine STR13 A mixture of 4,6-dichloropyrimidine (223.5 g, 1.5 mol), potassium fluoride (279.6 g, 4.8 mol) and tetrabutylammonium bromide (6.0 g, 0.0186 mol) in sulfolane (1 L) is heated at 180-190° C. for 3.5 hours and distilled to give the title product as a white liquid (115 g, 66% yield).
References:
American Cyanamid Company US5977363, 1999, A