4-bromo-2,6-dichloropyridine synthesis
- Product Name:4-bromo-2,6-dichloropyridine
- CAS Number:98027-80-6
- Molecular formula:C5H2BrCl2N
- Molecular Weight:226.89
2587-02-2
314 suppliers
$12.40/250mg
98027-80-6
119 suppliers
$9.00/100mg
Yield:-
Reaction Conditions:
with copper(ll) bromide in Isobutyronitrile;acetonitrile at 0 - 20; for 12 h;
Steps:
17.A
4-bromo-2,6-dichloropyridineTo a suspension of copper (II) bromide (8.2 g) in acetonitrile was added t-butylnitrile (5.5 mL) at O0C 4-amino-2,6-dichloropyridne (5.0 g) in acetonitrile. The mixture slowly warmed to room temperature and stirred for an additional 12 h. The mixture was poured into 2N HCl and extracted with ethyl acetate, washed with brine, dried over magnesium sulfate, and concentrated. The title compound was recrystallized from toluene/hexanes (4.5 g).
References:
MERCK & CO., INC. WO2007/21710, 2007, A1 Location in patent:Page/Page column 42