ChemicalBook CAS DataBase List 4-BROMO-6-FLUORO (1H)INDAZOLE

4-BROMO-6-FLUORO (1H)INDAZOLE synthesis

7synthesis methods

Product Name:4-BROMO-6-FLUORO (1H)INDAZOLE
CAS Number:885520-70-7
Molecular formula:C8H5BrFN
Molecular Weight:214.03

Pyrrolidine, 1-[2-(2-bromo-4-fluoro-6-nitrophenyl)-1-methylethenyl]-

1093066-65-9

885520-70-7

1-Bromo-5-fluoro-2-methyl-3-nitrobenzene (7.49 g, 31.8 mmol) was used as a raw material, which was dissolved in dioxane (40 mL) and then DMF-DMA (21.0 mL, 158 mmol) and pyrrolidine (2.6 mL, 31.1 mmol) were added sequentially. The reaction mixture was heated at 100 °C for the reaction. After completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure to remove the solvent to afford 1-[2-(2-bromo-4-fluoro-6-nitrophenyl)-1-methylethenyl]-pyrrolidine as a dark red residue (10.0 g, theoretical amount). This pyrrolidine derivative (10.0 g, 31.7 mmol) was mixed with Raney nickel (suspended in water, 15 mL) in MeOH:THF (1:1, 150 mL), and hydrazine monohydrate (2.3 mL, 47.4 mmol) was added slowly at 0 °C, followed by stirring the mixture for 5 h at room temperature. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filter cake was washed with EtOAc. The filtrates were combined and concentrated to dryness under reduced pressure to afford the title compound 4-bromo-6-fluoro-1H-indole as a light colored oil (2.57 g, 37% yield). NMR hydrogen spectrum (300 MHz, CDCl3) δH 6.57 (apparent triple peak, J = 2.7 Hz, 1H), 7.04 (double-double peak, J = 2.1, 9.1 Hz, 1H), 7.12 (double-double peak, J = 2.1, 9.1 Hz, 1H), 7.20-7.25 (multiple peaks, 1H), 8.25 (single peak, 1H).

Ethenamine, 2-(2-bromo-4-fluoro-6-nitrophenyl)-N,N-dimethyl-

1354219-92-3
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885520-70-7
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Yield:885520-70-7 800 mg

Reaction Conditions:

with iron;acetic acid at 110; for 1.5 h;

Steps:

110.3 3rd step

An acetic acid (20 ml) solution containing the deep brown oily matter obtained in the 2nd step was added to amixture of iron powder (3.61 g) and acetic acid (20 ml) at 110°C for 30 minutes. The resulting mixture was stirred for 1hour and then diluted with ethyl acetate. Insoluble matter was removed by filtration with Celite, the filtrate was washedwith water and 1M hydrochloric acid (x3). The obtained organic layer was poured into a saturated aqueous sodiumhydrogen carbonate solution to separate the organic layer, and the organic layer was washed with water and saturated saline and dried over anhydrous sodium sulfate. Thereafter, activated carbon was added and insoluble matter wasremoved by filtration with Celite. The solvent was distilled away under reduced pressure, and light brown oily matter of4-bromo-6-fluoro-1H-indole (880 mg) was thus obtained.MS (ESI m/z): 214, 216 (M+H)RT (min): 1.561H-NMR (DMSO-d6, 300MHz) δ:11.53 (br, 1H), 7.46 (t, 1H, J = 3.0Hz), 7.24 (dd, 1H, J = 5.6, 3.0 Hz), 7.19 (dd, 1H, J =9.2, 2.0Hz), 6.39 (d, 1H, J = 2.0Hz)

References:

EP2589592,2018,B1 Location in patent:Paragraph 0755; 0758

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885520-70-7
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References

4637-24-5 Synthesis