4-Bromo-N-methoxy-N-methylpicolinamide synthesis
- Product Name:4-Bromo-N-methoxy-N-methylpicolinamide
- CAS Number:1005342-94-8
- Molecular formula:C8H9BrN2O2
- Molecular Weight:245.07
Yield:1005342-94-8 100%
Reaction Conditions:
with triethylamine;HATU in N,N-dimethyl-formamide at 20; for 2 h;
Steps:
328
To a solution of 4-bromo-pyridine-2-carboxylic acid (5.0 g, 24.8 mmol, 1.0 eq) in DMF (10 mL) was added Et3N (7.5 g, 74.4 mmol, 3.0 eq), Ο,Ν-dimethyl-hydroxylamine (2.41 g, 24.8 mmol, 1.0 eq) and HATU (11.3 g, 29.8 mmol, 1.2 eq). The reaction mixture was stirred at rt for 2 h. Water was added, and the mixture was extracted with EtOAc. The organic layer was washed with water, dried over Na2S04, filtered, and concentrated to give the crude product which was subject to silica gel chromatography (PE/EA = 5/1-2/1, v/v) to afford 4-bromo-pyridine-2-carboxyl .0 g, 100%) as a white solid.
References:
WO2015/103317,2015,A1 Location in patent:Page/Page column 347
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